Latest technologies from Georgia Health Sciences University

In Vivo Delivery and Removal of Metals

mmoore9@augusta.edu — Tue, 18 Nov 2025 07:26:29 GMT

Current State of the Art: Gold-based drugs are currently used in the treatment of rheumatoid arthritis, have demonstrated efficacy in clinical trials in malaria treatment, and most recently have significantly reduced the reservoir of viral DNA and the population of long-lived HIV-infected memory CD4+ cells in pre-clinical studies. In addition, chelation therapy is a mainstream treatment used to treat heavy metal poisoning. However, chelation therapy is also used as an alternative therapy (and not approved by the FDA) for treatment of heart disease, cancer, and oth...

PD1+CD38+ CD8 T-cells, a marker for anti-PD1 therapy resistance and selection marker for treatment or continuation of treatment of patients, and a target to reverse resistance

mmoore9@augusta.edu — Thu, 29 Aug 2024 12:37:58 GMT

PD1+CD38+ CD8 T-cells, a marker for anti-PD1 therapy resistance and selection marker for treatment or continuation of treatment of patients, and a target to reverse resistance Current state of the artA number of new checkpoint inhibitors are used in cancer therapy. PD-1 inhibitors such as Pembrolizumab (Keytruda), Nivolumab (Opdivo), and Cemiplimab (Libtayo), and PDL-1 inhibitors such as Atezolizumab (Tecentriq), Avelumab (Bavencio),and Durvalumab (Imfinzi) are used to treat cancers such as melanoma of the skin, non-small cell lung cancer, kidney cancer, bladder cancer, head and neck canc...

Crosslinking proteins to RBCs (protein-RBCs) with EDC can be improved with sulfo-NHS +/- sulfo-NHS-acetate

mmoore9@augusta.edu — Tue, 11 Jul 2023 06:40:57 GMT

Intravenous infusion of protein/peptide antigens linked to lymphocytes with ethylene carbodiimide (EDC) is a highly efficient method for inducing peripheral, antigen-specific T cell tolerance for the treatment of autoimmune disease. Likewise, red blood cells (RBC) can be used to deliver protein/peptide antigens for treatment of autoimmune disease. EDC alone to couple proteins or peptides to RBCs grossly damages RBC membrane and reduces resistance to lytic agents. A method using EDC, with N-hydroxysuccinimide (NHS), eliminates damage to RBC's in the current invention. RBC's ca...

A Transcriptomic Classifier of Gliomas

mmoore9@augusta.edu — Fri, 07 Apr 2023 07:54:15 GMT

The current state of the art:Gliomas account for about 27% of all brain tumors and about 80% of the malignant tumors. Currently, Glioma is classified by histology and the gene mutation test (isocitrate dehydrogenase, IDH) defined by the world health organization (WHO). The problems with the current art:However, there is a big discrepancy between histology and gene mutation testing; their concordance rate is 82%. Moreover, histology diagnoses depend on human pattern recognition and are prone to errors and bias. The advantages of our invention:Scientists at AU developed novel transcri...

Antibody specific for PKG-1alpha nitration

mmoore9@augusta.edu — Thu, 12 Aug 2021 11:44:15 GMT

Scientists at AU identified that nitration of PKG-1α in tyrosine 247 attenuates the catalytic activity of PKG-1 α, which plays a critical role in the development of vascular dysfunction in pulmonary hypertension and other vascular pathologies. The inventors developed the humanized monoclonal antibody or antigen-binding fragment for detecting nitrated tyrosine 247 of PKG-1 α. Further, the antibody or antigen-binding fragment can be labeled with a detectable marker or conjugated to a second molecule, such as a radioisotope, a fluorescent compound, a bioluminescent compound, b...

Effect of GHRH Antagonists in Type 2 Diabetes and Obesity

mmoore9@augusta.edu — Thu, 03 Jun 2021 11:47:47 GMT

The current state of the art Triglyceride-rich-lipoproteins (TRL), that are generated in the small intestine as chylomicrons and the liver as very-low-density lipoprotein (VLDL), and their remnants represent an important risk factor for cardiovascular disease (DVD) in people with diabetes, obesities, or metabolic syndrome. The problems with the current art Despite statin, HMG-COA reductase inhibitor and PCSK9 inhibitors are available to lower cholesterol levels, there is still a needs to identify new targets and develop treatments to treat obesity/diabetes-associated dyslipidemia and to low...

Use of arginase 1 as a treatment for retinopathy

mmoore9@augusta.edu — Tue, 01 Jun 2021 14:53:18 GMT

The current state of the art Ischemia retinopathies cause retinal neurovascular injury and are a primary contributor to blinding disease that affects neonates (retinopathy of prematurity), working-age adults (diabetic retinopathy), and the elderly (branch vein occlusion and age-related macular degeneration). The problems with the current art Despite the use of anti-VEGF, laser, or surgery-based treatments in Ischemic-retinopathies including retinopathy of prematurity, diabetic retinopathy, age-related macular degeneration, novel and effective medicines to treat these pathologies are still ...

Title: Engineered Exosome Delivery System to detect and deplete pro-tumorigenic macrophages

mmoore9@augusta.edu — Fri, 28 May 2021 11:08:02 GMT

The current state of the art: Despite the advancement in immunotherapy and other targeted therapy for the treatment of cancer, the success rate remains low in solid tumors. Targeting the tumor microenvironment (TME) is a new promising treatment strategy. Infiltrated in TME, tumor-associated macrophages, especially CD206 positive M2 macrophages, play a pivotal role in tumor development and metastasis, especially in breast cancer. As a result, removing CD206 positive M2 macrophage can be a promising therapeutic candidate. The problems with the current art: An effective drug delivery ...

Novel TREM1 inhibitor for pathological inflammatory response

mmoore9@augusta.edu — Wed, 26 May 2021 11:54:50 GMT

The current state of the art Trigging receptor expressed on myeloid cell 1 (TREM-1) plays a critical role in the pathogenesis of acute and chronic cardiovascular conditions, and is a crucial mediator of septic shock, especially, in cytokine release syndrome. Inhibiting TREM-1 is a promising therapeutic candidate for TREM-related diseases such as inflammatory disease, cardiovascular disease, and cancer. Problems with the current art Currently, TREM-1 inhibitors include peptides, TREM-1 Fc fusion protein, small molecules, and monoclonal antibodies. However, available TREM-1 inhibitors stil...

Adenovirus Survivin for Detection or Treatment of Uterine Leiomyosarcoma

mmoore9@augusta.edu — Tue, 25 May 2021 12:53:44 GMT

The Current State of Art Uterine sarcoma, though with very low incidence (4% of uterine cancer), has a high malignant degree and poor prognosis. Leiomyosarcoma is the most common type of uterine sarcoma and usually occurs in women over 40 years. Proper differentiation between benign leiomyoma and malignant uterine leiomyosarcoma can dramatically improve the efficacy of patient treatment modalities, as leiomyosarcoma has a poor prognosis. Problems with the current art: However, the limitations of current diagnostic tests warrant more research in leiomyosarcoma diagnosis. For exampl...

Deep Brain Stimulation for the Treatment of Non-Alzheimer's Dementia

mmoore9@augusta.edu — Tue, 25 May 2021 08:06:04 GMT

The current state of the art The current treatment option for Alzheimer’s disease and aging related dementia are focused on the alleviation of symptoms and managing cognition. Degeneration of cholinergic neurons is one of the mechanisms leading to cognition declination. Therefore, aging and Alzheimer’s dementia is commonly treated with cholinesterase inhibitors such as galantamine, rivastigmine, or donepezil. The problems with the current art Although the extended time of action of acetylcholine in the central nervous system can improve cognition. systematic c...

Methods and Compositions for Treating Neurodegenarative Diseases

mmoore9@augusta.edu — Thu, 25 Mar 2021 11:00:46 GMT

The current state of the art: Neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and multiple sclerosis pose devastating threats to both patients and their caregivers. Although palliative measurements are available to manage the disease symptoms, effective treatments are still lacking. The problems with the current art: Moreover, the number of neurodegenerative diseases is expected to double every 20 years as the average age of the world population increases. Therefore, there is an urge...

Compositions and methods to increase the resistance of adoptive transfer of T cells to immunosuppression

mmoore9@augusta.edu — Tue, 16 Mar 2021 05:25:32 GMT

The current state of the art: Cancer immunotherapy resurrects the patients’ suppressed immune system by increasing the immunogenicity of T cells such as the adoptive transfer of T cells (TCR and CAR T cells) and removing suppression of immune checkpoints such as PD-1/L1. Many cancer immunotherapies have been approved by the FDA. For example, Yescarta (CAR T therapy) has been approved to treat lymphoma; Keytruda (PD-1 inhibitor) has been approved to treat melanoma, lung cancer, head and neck, Hodgkin lymphoma, and stomach cancer. The problems of the current art: Whi...

Compositions and Methods for treating diabetes

mmoore9@augusta.edu — Thu, 11 Mar 2021 12:29:07 GMT

The current state of the art About 10% of the US population, 34.2 million people, have diabetes and about 34.5% of the US adults, 88 million people, have prediabetes (higher than normal blood sugar). Exercise has been shown to improve glycemic control in patients with type 2 diabetes through increasing energy expenditure and insulin-induced membrane translocation of GLUT4 and anti-inflammatory properties. Problems with the current art However, exercise can be strenuous, time-consuming, and difficult to maintain given today’s rapid-paced digital society. There is a need to devel...

Chimeric Antigen Receptor T Cells and Methods of Use Thereof

mmoore9@augusta.edu — Mon, 08 Mar 2021 12:25:46 GMT

The current state of the art With four FDA-approved therapies (Axicabtagene ciloleucel, Brexucabtagene autoleucel, lisocabtagene maraleucel, and Tisagenlecleucel), the adoptive T cell (ACT) therapies’ market is attracting more investment. Although ACT has shown some successful clinical application, it has not been effective in treating most solid tumors. Moreover, some patients failed to respond to treatment or succumbed to late relapse after the initial response. The problems with the current art Studies have shown co-presence of CD4+ and CD8+ T cells are correlated with favor...

Curcumin Conjugates and Methods of Use Thereof

mmoore9@augusta.edu — Mon, 01 Mar 2021 13:21:51 GMT

The current state of the art Breast cancer is the second most common cancer in women with an estimated 268,600 cases in 2019 and 41,760 deaths in the US. Curcumin, a phenolic compound and the major ingredient in the spice, turmeric, has anti-inflammatory and pro-apoptotic activities against many solid tumors. The problems with the current art Curcumin is one of the well-studied molecules for anticancer properties; however, it has poor bioavailability when given orally and poor tissue penetrance when infused. Dichloroacetate (DCA) is an anticancer drug and inhibits PDK1 at micromolar ...

Florida has lead - Communication and Skills Training Using Interactive Virtual Humans

mmoore9@augusta.edu — Tue, 09 Feb 2021 05:18:19 GMT

Current State of the Art: Many health profession students are inexperienced in breast examination skills. As a result, they lack confidence and can score poorly on initial breast exam tests. This has occurred in large part due to a lack of sophisticated training equipment available. Previously, students would examine silicone breasts without sensors for abnormalities. Over the past decade, however, breast simulators have been evolving. The newest models are fitted with sensors that can give students feedback on whether they're doing an ex...

Development of H295R Adrenal Cancer Cell Clones as Potentially Improved Cell Culture Model Systems to Study Steroidogenesis

mmoore9@augusta.edu — Thu, 04 Feb 2021 05:25:16 GMT

Title: Human Adrenal Carcinoma Cell Line Clones: Improved Models for Steroidogenesis. Current State of the Art: Steroidogenesis is the production of hormones from cholesterol including aldosterone (regulates potassium in the blood) and corticosteroids (stress reponse). These hormones are primarily produced in the adrenal gland. Diseases and disorders of steroidogenesis in the adrenal glands include primary aldosteronism (PA). PA is the most common form of hormonally induced hypertension affecting ~8-10% of hypertensive subjects. Cell culture model systems offer a rapid and easily malleable a...

Bispecific CD44 and EpCAM aptamer inhibits ovarian cancer growth

mmoore9@augusta.edu — Thu, 04 Feb 2021 05:07:34 GMT

The current state of the art Like Antibodies, small nucleotide aptamers target specific biomarkers responsible for tumor progression. But they have no-immunogenicity, higher tissue penetration, higher specificity, and higher binding affinity than antibodies. Problems with current state of art Single CD44 aptamers and single EpCAM aptamers have been studied for treating ovarian tumorigenesis but their clinical application is limited due to their small size, susceptibility to nuclease attack, and short circulation half-life. Advantages of our invention Researchers...

Bivalent aptamer-dual siRNA chimera effectively suppresses prostate cancer

mmoore9@augusta.edu — Thu, 04 Feb 2021 05:06:34 GMT

Current State of the Art Both aptamer and RNAi therapies are promising treatments for a wide range of diseases. Anti-VEGF aptamer was approved by FDA in 2017 for treating wet (age-related) macular degradation. The only FDA approved RNAi therapy is Patisiran for treating hereditary transthyretin amyloidosis with neuropathy. Aptamer and RNAi therapies in cancer are being tested in clinical trials, but the efficacy is not conclusive. Problems with the current state of art RNAi therapy is limited to liver disease because the current siRNA delivery system only ta...

Targeting EGFR/HER2/HER3 with a three-in-one aptamer-siRNA chimera

mmoore9@augusta.edu — Thu, 04 Feb 2021 05:06:09 GMT

Current State of the Art Treatments that target one protein or gene are effective for some cancer and infectious disease. However, clinical studies showed that many patients do not respond or develop resistance to one-target treatments. Therapies with more than one targets are needed to improve clinical efficacy and expand clinical application. Problems with the Current Art To this end, biopharmaceutical companies are pursuing bispecific and pan antibody therapies: one pan-HER antibody mixture is in the clinical trial; one bispecific antibody for the treatment of B-cell acute ly...

Modified Green Tea Polyphenol EGCG and EGCG-ester Inhibit Endospores

mmoore9@augusta.edu — Fri, 15 Jan 2021 13:52:36 GMT

Modified Green Tea Polyphenol EGCG and EGCG-ester Inhibit Endospores Researchers at Augusta University have invented skin-friendly compositions and methods for killing, inactivating, or otherwise reducing the bacterial endospores by using an effective amount of the green tea EGCG or its derivatives. EGCG research shows clear application for a hand sanitizer solution that contains no alcohol, and yet, is more effective in disease control. This technology can also be used in a variety of other applications, for example, to increase the shelf-life of a food by reducing the spoilage of ...

Method for Real-Time, Non-Invasive Intracranial Pressure Monitoring

mmoore9@augusta.edu — Thu, 14 Jan 2021 11:15:35 GMT

The current state of the art The market for Brain function monitoring is growing rapidly as a result of the increased incidence of neurological and neurodegenerative disorders. At a CAGR of 6.2%, the market is estimated to grow from USD 6.3 billion to 8.6 billion. Problems with the current art The current methods of monitoring brain function have restricted application. For example, the Glasgow Coma Scale (GCS) tests the patient’s consciousness to assess crude gross brain measurement and monitoring. An intracranial monitoring device, monitoring changes of intracranial pressure (ICP...

Quantification by Ultrafiltration and Immunofixation Electrophoresis Testing (QUIET) for monoclonal serum free light chains

mmoore9@augusta.edu — Mon, 04 Jan 2021 13:25:00 GMT

The current state of the art: Plasma cell myelomas is a plasma cell disorder that is associated with the presence of monoclonal immunoglobulin or fragments secreted by a B-cell clone. It can be detected and monitored by the presence of free monoclonal light chains. Currently, the serum free-light-chain (sFLC) assay is the most analytically sensitive assay on the market. It measures the ratio of free kappa (κ) and lambda (λ) light chain. The abnormal ratio (<0.26 or >1.65) indicates the presence of monoclonal proteins. The problems with the current art: However, s...

Ibuprofen hybrid conjugates as potential anti-inflammatory and analgesic agents

mmoore9@augusta.edu — Wed, 26 Aug 2020 12:33:55 GMT

The current state of the art: Nonsteroidal anti-inflammatory drugs (NSAIDs) have broad therapeutic use that ranges from the treatment for fever, inflammation, and mild pain to severe chronic inflammatory disorders. NSAIDs mainly act by COX 1 inhibition, the key enzymes capable of the conversion of arachidonic acid to prostaglandins. Therefore, the long term use of NSAIDs may lead to severe gastrointestinal damage and renal dysfunction. The problems of the current art: The development of a completely selective NSAID toward COX2 is still a long-standing problem. The advantages of our inven...

Pyrazinoic acid-isoniazid hybrid conjugates’ antimycobacterial and antibacterial properties

mmoore9@augusta.edu — Wed, 26 Aug 2020 12:25:48 GMT

The current state of the art: Tuberculosis is one of the top 10 causes of death worldwide. Patients are treated for two months with first-line drugs including isoniazid, rifampin, pyrazinamide, and ethambutol, followed by another four months of isoniazid and rifampin alone. The problems of the current art: However, the multidrug-resistant disease occurs when patients develop resistance to isoniazid and rifampin. Current existing drugs are of limited efficacy against drug-resistant tuberculosis. The advantages of our invention: AU scientists synthesized novel pyrazinoic acid and iso...

CAR-T cell compositions and use in hepatocellular carcinoma

mmoore9@augusta.edu — Fri, 08 May 2020 11:37:45 GMT

The current state of the art The majority of liver cancers, the 2nd leading cause of cancer death among adult men, are hepatocellular carcinoma (HCC). About 70-80% HCC tumors, but not normal hepatocytes, express glypican 3 (GPC3), a cell surface antigen. Thus, GPC3 might be a great target for HCC immunotherapy, especially chimeric antigen receptor-modified T cell therapy (CART). The limitation of the current art The current CARTs against HCC target one epitope of GPC3. GC33 is the only mAb that has advanced to the clinical trial. But its efficacy is still being evaluated. Moreover, GC33 ...

Deformylase, a new drug to improve survival in Sepsis

mmoore9@augusta.edu — Fri, 01 May 2020 06:33:21 GMT

The Current State of The Art Sepsis is the world’s third leading cause of death and the leading cause of death for infants and children. Sepsis management is one of the most expensive in-patient hospital care. The current treatments include antibiotics and IV fluid to reduce inflammation and control blood pressure. The Problem of the Current Art The antimicrobial resistance has limited the effectiveness of antibiotics in protecting the body from a bacterial attack in sepsis. There is clearly a clinical need for more effective treatments that can prevent the organ a...

Mitochondrial-Targeted Peptide Modulators of Delta Protein Kinase C Interaction with the d-subunit of F1Fo ATP Synthase/ATPase as Therapeutics Against Cardiac Injury

mmoore9@augusta.edu — Wed, 29 Apr 2020 11:03:18 GMT

Current State of the Art: Current clinical therapy for heart attack victims focuses on the rapid restoration of blood flow by thrombolysis, angioplasty, stenting and when appropriate surgical coronary artery bypass grafts. Problems with the Current Art: The majority of cardiac cell death associated with a heart attack actually occurs during the early phases of reperfusion when blood flow is restored. Cardioprotective agents that minimize cell death during reperfusion therapy are desperately needed and would greatly improve the outcomes of these patients. Advantages...

A Mouse Model for Mental Disorders and Epilepsy

mmoore9@augusta.edu — Wed, 29 Apr 2020 11:03:04 GMT

Current State of the Art The Neuregulin/ErbB4 signaling pathway is involved in GABAergic neurotransmission, an important inhibitory neurotransmission that regulates several processes in the central nervous system including muscle tone. Aberrant GABAergic function has been implicated in Schizophrenia, Schizo-affective disorder and in Epilepsy. Clinically overlap has been observed in the development of Schizophrenia, Schizo-affective Disorder and Epilepsy. In some cases treatments for one disorder can cause symptoms of the other. This implies common pathways intertwine in the developme...

Combination therapy for hemorrhagic shock

mmoore9@augusta.edu — Tue, 28 Apr 2020 06:44:07 GMT

Combination Therapy for Hemorrhagic Shock Current state of the art Crystalloid and colloid solutions, hypertonic saline, oxygen-carrying blood substitutes, and transfusion are all treatments for hemorrhagic shock. They replenish decreased blood volume in order to stabilize the patient and improve survival, especially during the golden hour. The goal is to restore radial pulse or sensorium or achieve minimum blood pressure until further medical treatment can be given. Problems with current state of art Resuscitation with these solutions may be successful in saving a patient&...

Blockchain Technology with Hybrid Models: Health Analytics and Pre-emptive Therapy options to save patients

mmoore9@augusta.edu — Fri, 06 Mar 2020 09:03:47 GMT

The current state of the art:Healthcare-associated infection (HAI) places a significant burden on the patients and the health care system. It is estimated that 3% of hospitalized patients had one or more HAI in 2015. It accounts for about 1.7 million infections and 99,000 death per year. On the other hand, the Centers for Medicare and Medicaid Services no longer provide reimbursement for care required for several types of HAI. Therefore the timely detection of HAI is needed to improve patient care and reduce healthcare costs. The problems with the current artHAI can be detected via cultur...

Progesterone Formulation to Trigger Ovulation

mmoore9@augusta.edu — Tue, 28 Jan 2020 12:37:48 GMT

The current state of Art Triggering ovulation is a crucial step in the management of the controlled ovarian stimulation in patients undergoing IVF, IUI, timed intercourse and other forms of fertility therapy. Currently, human chorionic gonadotrophin (hCG), is the only FDA-approved medication to trigger ovulation. The problems with the current art But hCG can cause a high incidence of ovarian hyperstimulation syndrome; in serious cases, patients can experience blood clots, shortness of breath, abdominal pain, dehydration, and even death. Although other therapies are being ...

Protocol To Differentiate Adult-Type Neural Stem Cells Using Novel Ceramide Analogs (NCAs) and Sphingosine-1-Phosphate Receptor Agonists (SRAs)

mmoore9@augusta.edu — Mon, 06 Jan 2020 13:13:36 GMT

Use of Sphingolipids in cell culture to inhibit pluripotent stem cell-derived teratoma formation The current state of the art: Stem cells are capable of self-renewal into more and differentiation specialized cells, making them one of the most promising restorative medicine. However, the pluripotent stem cells can form fast-growing, noncancerous tumors called teratomas, which has impeded the development of stem cells into regenerative medicines. The problems of the current art: There are some experimental methods to inhibit teratoma formation. For example...

Use of GILZ for Hair Growth

mmoore9@augusta.edu — Wed, 04 Dec 2019 12:34:52 GMT

The current state of art: Hair loss, also known as androgenetic alopecia affects roughly 50% of men and 75% of women older than 65 years. In the US, it affects an estimated 50 million men and 30 million women. Current FDA-approved drugs for hair loss include Finasteride and Minoxidil. Problems with current state of art: However, Finasteride, a 5α-reductase inhibitor, has caused undesirable adverse effects such as impotence and reduced libido. Although Minoxidil has not shown any safety concern, the efficacy of Minoxidil is low: less than 40% of the patients responded to t...

Topical Application of GILZ Formulation for Wound Healing

mmoore9@augusta.edu — Tue, 15 Oct 2019 08:12:04 GMT

The current state of the art: The primary objectives of wound healing include timely wound closure, prompt pain relief, reduced bacteria contamination, and an esthetically acceptable scar. The currently available wound dressings such as semiocclusive, hydrocolloids, and alginates, are used to heal wounds by creating a moist and clean environment to reduce bacteria colonization. Problems with current state of art However, if the wounds do not heal within 48 hours, they eventually become hosts to bacteria and get infected. While some antimicrobial dressing such as silver dressing h...

Near-IR activated, violet/blue-emitting adhesive liner containing 2-photon, up-converting nanoparticles for dental bonded restorations

mmoore9@augusta.edu — Fri, 11 Oct 2019 11:11:51 GMT

Current State of the Art In dental bonded restoration technique, a methacrylate-based semi-viscous agent (liner) is placed on the prepared tooth structure. This liner is exposed to blue or violet light, which enables the liner to bond to the tooth. Following this, the missing tooth structure is filled with glass-filled composite, the top of which is exposed to blue/violet to polymerize. The Problems of the Current Art The light exposure of the composite from the top shrinks the top rapidly, which leads to stress development between the composite and bonding liner. This stre...

Autologous or Allogeneic Mesenchymal Stem Cell Therapy for Premature Ovarian Failure and other forms of ovarian-based female infertility

mmoore9@augusta.edu — Tue, 13 Aug 2019 11:40:58 GMT

Premature ovarian failure (POP) is defined as hypergonadotropic ovarian failure occurring prior to age 40. AU researchers used human bone marrow mesenchymal stem cells to reverse infertility in a chemotherapy induced ovarian failure mouse model. The cells were delivered by direct intra-ovarian injection. The treatment were successful with all treated mice achieving viable pregnancy and producing pups, overall the number of pups were about 30% compared to that achieved by healthy controls. All delivered pups appeared with normal morphology with no apparent anomalies or abnormalities. They were ...

Manipulation of the p53 pathway as a novel target for cancer immunotherapy

mmoore9@augusta.edu — Tue, 13 Aug 2019 11:37:45 GMT

AU researchers have identified a novel population of immunogenic dendritic cells that arise from rapid transdifferentiation of immature myeloid-derived suppressor ceils (MOSCs) in tumors. We have discovered that this DC trans-differentiation step is driven by p53 expressed by the host (not the tumor). Mice with a deletion of p53 in host cells lose exactly this Ly6c+CD103+ DC population (and no others), and they become selectively unable to respond to all forms of anti-tumor immunotherapy that we have tested. Conversely (and with major implications for clinical immunotherapy) if we artificially...

Combinatorial Therapeutic for Breast and Prostate Cancer Treatments

mmoore9@augusta.edu — Tue, 13 Aug 2019 11:23:09 GMT

Title Combinatorial Therapeutic for Breast and Prostate Cancer Treatments Present State of the ArtHsp90 (heat shock proteins) are popular cancer drug targets due to their anti-apoptotic activities. Several classes of Hsp90 inhibitors are in clinical trial. Problem of the Present ArtHsp90 inhibitors are often successful in diminishing or deactivating the Hsp90 in the cancer cells. However, inhibition of Hsp90 is associated with the overexpression of Hsp70 and its anti-apoptotic activity. Advantage of InventionResearchers at GRU discovered that a certain capsaicinoid class of comp...

Surgical Apparatus for Cutting Tissue

mmoore9@augusta.edu — Tue, 13 Aug 2019 11:04:32 GMT

Title: Single surgical instrument uses unique design for cutting membranes covering tissue.Current State of the Art: There are several surgical procedures that require the cutting and re-positioning of a membrane in order to access the underlying tissues. These include but are not limited to the dura mater of the brain and spinal cord. To perform these procedures surgeons need surgical grade instruments that allow them to cut a slit in the membrane, hold the membrane up and support and separate the membrane from the underlying tissue, as the surgeon re-positions and continues to cut a sufficie...

GA Tech has lead - Microirradiator for Treatment of Skin Tumors

mmoore9@augusta.edu — Tue, 13 Aug 2019 11:04:10 GMT

Current State of the Art: The incidence of cancer is rising worldwide, with more than 11 million cases recorded annually. Incidence is expected to increase further, driven by rising life expectancy rates and aging global population. This is expected to increase the demand in the radiation therapy market which is currently experiencing technological advancements leading to more effective therapy that is precise and commercially viable. Highly accurate and targeted radiation therapy has the potential to replace surgery, driving the demand for radiation therapy equipment to over $3.6 bi...

A Novel SUMO-like Gene for Type 1 Diabetes Susceptibility

mmoore9@augusta.edu — Tue, 13 Aug 2019 11:02:09 GMT

Current State of the Art: Type 1 diabetes is an organ-specific autoimmune disease with aberrant immune responses to specific β-cell autoantigens. Prevention is important because diabetes interrupts normal development in children and carries the threat of severe complications in the most active period of life. Both environmental and genetic factors play etiological roles. The most informative genetic locus, HLA class II, confers about half of the total genetic risk, but has low positive predictive value when used alone in the general population1. Autoantibodies pr...

Use of Novel Gradient Directions with Diffusion to MRI to Synthesize Complex Diffusive Geometrics

mmoore9@augusta.edu — Tue, 13 Aug 2019 11:01:59 GMT

This invention provides a phantom, or a test object, which includes anisotropic structures, which can be used to monitor DTI measures. The anisotropic structures include a plurality of water-filled capillaries, arranged in a predefined configuration. In addition to using the phantom for providing quality assurance (QA) measurements of DTI in a conventional manner, data scanned using a phantom of the present invention having simple, prolate geometry can be employed to synthesize ADC distributions that exhibit complicated behavior. The method of the present invention may be used for studying an...

Rescaling of Image Intensities with Diffusion MRI to Synthesize Complex Diffusive Geometries

mmoore9@augusta.edu — Tue, 13 Aug 2019 11:01:49 GMT

This invention is composed of a phantom and DTI bench marking that allows DTI to proceed, applicable to tissue structures found throughout the body. Bench marking of DTI data will allow for a host of benefits, including 1) appropriate comparison of DTI data within multi-center trials; 2) appropriate ranges of uncertainty that could be presented with an examination, to improve the characterizing of tissue (for example, tumor demarcation, white matter infiltration) for pre-surgical planning; 3) characterization of MR scanner performance over time at an institution, for maintenance decisions; 4)...

Sensitive Detection of Peptide Fragments Specific to Galectin-3 for the Detection and Monitoring of Well-differentiated Thyroid Cancer, Head and Neck Cancer, Lung Cancer, Colorectal Cancer and Other Cancers and Disease States

mmoore9@augusta.edu — Tue, 13 Aug 2019 11:01:00 GMT

Current State of the Art:The detection of head and neck cancers, i.e. thyroid cancers, colorectal and other types of cancers are normally done via MRI or other non-specific tests. Problems with the Current Art:Such tests are not as accurate or time sensitive to identify the progression of the tumor in its early stage. Advantages of the Novel Invention: In order to more effectively and accurately identify the presence of such cancers, specific biomarkers have been identified that can be traced to the presence of head and neck tumors using MS and other related analysis. Patent S...

Method and Apparatus for Light-Curing Resin Adhesives for Orthodontics Brackets

mmoore9@augusta.edu — Tue, 13 Aug 2019 11:00:30 GMT

Title: Method and Apparatus for Light-Curing Resin Adhesives for Orthodontics Brackets Current State of the Art: Hardening of dental resins through light curing is a commonplace procedure when bonding materials including the dental brackets associated with braces, to the teeth of dental patients. Braces are used to correct dental flaws and improve dental health, often to correct malformations of the jaw and palate or misalignment of teeth including underbites, malocclusions, overbites, cross bites, open bites and deep bites. Disadvantages with the Current Art: The procedure f...

Development of an Orthodontic Bracket Placement Device and Coordinated Bracket Placement System

mmoore9@augusta.edu — Tue, 13 Aug 2019 10:59:22 GMT

Title: Orthodontic Bracket Placement Device and Coordinated Bracket Placement System Current State of the Art: Orthodontic brackets are used by general dentists and orthodontists throughout the world. The proper placement of these brackets is essential for eventual correction of poorly aligned teeth in both children and adults. In order to guide tooth movement during orthodontic treatment, orthodontic brackets are placed at precise vertical positions on the teeth. Disadvantages with the Current Art: The difficultly in accurately placing orthodontic brackets for proper guidance of to...

Prodrugs of Short-Chain Fatty Acids for Treatment of Intestinal Disorders and Colon Cancer

mmoore9@augusta.edu — Tue, 13 Aug 2019 10:59:01 GMT

Current State of the Art: Colon cancer, IBS, Crohn’s disease and colitis present as some of the most difficult diseases to treat with the medications available currently. Treatment can be as drastic as surgery, chemotherapy, medications, such as cortisone, which can have sometimes serious and debilitating side effects. Colon cancer is treated with radiation and chemotherapy. Crohn’s disease and ulcerative colitis are thought to be related to the autoimmune response and present many complications for which no single effective therapy exists. Problems with the Current Art: Use ...

Use of Integrating Sphere Technology To Provide Uniform, High-intensity Light and Wavelength Mixing from Light Emitting Diodes

mmoore9@augusta.edu — Tue, 13 Aug 2019 10:58:50 GMT

Current State of the Art: Since 2000, photoactive composites material used in fillings have become widespread in restorative dentistry. Cosmetically appealing, these white fillings have become the standard, increasing from approximately 68 million composite fillings in 1999 to close to an estimated 100 million procedures in 2011. Crowns remain a substantial portion of restorative dentistry with 43 million procedures estimated for 2011. To perform these restoration procedures, dentists use various light sources. To illuminate the patient’s oral cavity, a...

ATB0,+ as a Drug Target for the Treatment of Cancer

mmoore9@augusta.edu — Tue, 13 Aug 2019 10:57:52 GMT

The current state of the artCancer is a complex disease and is the result of many dysfunctional molecular events. By identifying the abnormal gene and proteins that are responsible for cancer growth and progress, target therapies are developed to treat cancer. The problem with the current artAlthough the current targeted therapies have improved survival times, patients develop drug resistance and undergo disease relapse. Therefore, there is a need for more targeted therapies to treat cancer. The advantages of our inventionScientists at AU identified an amino acid transporter protein ATB ...

HM74A/HM74 Ligands as Anti-Cancer and Anti-Diarrheal Drugs

mmoore9@augusta.edu — Tue, 13 Aug 2019 10:57:43 GMT

Tech ID: 2007-030: Compositions Comprising a GPR109 Ligand for Treating Disorders of the Digestive Tract and/or CancerState of the Art: Top drugs for colon cancer include Xeloda (Genetech), Erbitux (Johnson and Johnson), Eloxatin (Sanofi), and Gleevec (Novartis). These four drugs ranked in the top 10 selling cancer drugs of 2011 and totaled ~$4 billion out of $12.4 billion in total sales.Problems in the Art: Of the above listed best sellers, several have been on the market since 2002 or earlier and in some cases are close to the end of patent protection. Advantages of the Invention: This inven...

A Promoter Specifically Active in Newly Forming and Remodeling Arteries

mmoore9@augusta.edu — Tue, 13 Aug 2019 10:56:55 GMT

Current State of the Art: Studies in angiogenesis link new blood vessel formation to both wound healing and pathologies in the human body. Angiogenesis can be stimulated during regeneration of diseased or damaged tissues as well as during tumor growth and metastasis, in order to gain access to oxygen and nutrients necessary for survival. Gene therapy is a promising field to combat human disease by integrating new healthy gene products into a diseased or damaged state to influence recovery or impede disease progression. Gene therapies targeted to new blood vessels would improve ther...

Use of Polyanions to Remineralize Demineralized Dental Hard Tissues

mmoore9@augusta.edu — Tue, 13 Aug 2019 10:56:18 GMT

Current State of the Art:Tooth hypersensitivity affects 45 million adults in the United States and 10 million are chronically affected with sensitive teeth. Over time, the gums may recede or the enamel or dentin on the teeth may wear down, creating the condition for tooth sensitivity. In addition, cavities can destroy enamel creating a defect that often extends into the dentin or deeper. Restorative dentistry, including dentin bonding, plays an important role in the field of dentistry in restoring the tooth tissue to its form, function esthetics and in maintaining the physiolog...

Gene for Successful Aging Without Cognitive Decline

mmoore9@augusta.edu — Tue, 13 Aug 2019 10:55:37 GMT

Title: Biomarker for Successful Aging without Cognitive Decline Current State of the Art: It is estimated that up to one third of adults will experience a gradual decline in cognitive function known as mild cognitive impairment as they age. Individuals with cognitive decline are able to function reasonably well in everyday activities, such as managing finances and purchasing items at stores without assistance, but have difficulty remembering details of conversations, events and upcoming appointments. Most (but not all) patients with cognitive decline develop a progressive decline in their th...

Use of Dioleoylphosphatidylglycerol (DOPG) to Accelerate Corneal Wound Healing

mmoore9@augusta.edu — Tue, 13 Aug 2019 10:54:48 GMT

Current State of the Art: Corneal abrasions are typically allowed to self heal despite the discomfort and potential risk of infection. Lubricants, antibiotics and in severe cases eye patches are provided in an attempt to avoid contact with the eye as patients experience pain and discomfort while waiting for the long process of healing. These methods are also employed for post-operative procedures, again to alleviate irritation and pain during the healing process. Lubricants and eye patches are provided over the counter (OTC) while antibiotics require a prescription. Industry leaders in pro...

Peptide Antagonists Prevent Pulmonary Oxygen Toxicity

mmoore9@augusta.edu — Tue, 13 Aug 2019 10:54:35 GMT

Current State of the ArtPulmonary oxygen toxicity is a condition resulting from the harmful effects of breathing molecular oxygen at elevated partial pressures. Oxygen toxicity is a concern for scuba divers, those on high concentrations of supplemental oxygen (particularly premature babies), and those undergoing hyperbaric oxygen therapy. Problems with the Current ArtSupplemental oxygen in premature infants contributes to the development of bronchopulmonary dysplasia (BPD), and high-pressure oxygen delivery in general results in necrotizing bronchiolitis and alveolar septal injury. Currently,...

Development of Peptide Mimics of GM1 Ganglioside

mmoore9@augusta.edu — Tue, 13 Aug 2019 10:52:33 GMT

Tech ID: 2012-004 Title: Peptide Mimics for Treatment of GM-1 Associated Diseases Including Cholera and Guillain-Barre SyndromeCurrent State of the Art: Ganglioside GM1-associated diseases or infections are prevalent worldwide, and hundreds of millions of people are infected, or diagnosed, with ganglioside GM1-associated diseases each year. Exemplary diseases or disorders involving GM1 include, but are not limited to cholera, Guillain–Barré Syndrome (GBS), lupus, and enterotoxigenic Escherichia coli (ETEC) infection. Problems in the Current Art: Existing treatments for disorders involving GM1 ...

Stat5b transgenic lymphoma mouse model and therapeutic strategies

mmoore9@augusta.edu — Tue, 13 Aug 2019 10:43:50 GMT

Current State of the Art:Based on the age of the patient and the stage of lymphoma different regimens of radiation and chemotherapy are employed. In regard to drugs, most patients with early stage lymphoma are treated with a cocktail called "ABVD" chemotherapy, which contains the drugs Adriamycin (doxorubicin), bleomycin, vinblastine and dacarbazine. Later stage lymphoma may be treated with high levels of ABVD or different drugs with more aggressive regimens.Problems with the Current Art:Both the lymphoma and treatments suppress the patient's immune system, increasing the risk for in...

Development of Novel Therapies for Experimental Guillain-Barre Syndrome Using Ganglioside-Like Phage-Peptide

mmoore9@augusta.edu — Tue, 13 Aug 2019 10:42:38 GMT

Current State of the Art:Guillain Barre syndrome is currently treated by administering pain relievers and other palliative forms of care to reduce the symptoms associated with the disease. Guillain Barre currently affects about 1 out of 50,000 people world-wide and in some instances has proven to be fatal due to limited treatments readily available for the disorder. Problems with the current art:There are presently no cures for Guillain Barre syndrome. Although doctors can provide pain relief, they cannot cure the disease before it has serious health effects, sometimes leading to death. ...

Method and System for Measuring Dynamic Changes of Cardiac Pulse and Respiration Throughout Day/Night Cycle

mmoore9@augusta.edu — Tue, 13 Aug 2019 10:41:51 GMT

Current State of the ArtBreathing or pulse monitoring systems can be used to detect and monitor the heart and respiration rates in babies, to diagnose obstructive sleep apnea or monitor the vitality of a sleeping subject, and to monitor signs of cardiac arrest and respiratory distress at home or in healthcare settings. The available systems typically employ a camera system (e.g., Close View Monitor System) or a movement/sound system (e.g., Angelcare Movement Sensor w. Sound Monitor). Problems with the Current ArtThe available breathing and pulse monitoring systems use movement or sound s...

Differential Expression of MicroRNAs in Musculoskeletal Disorders

mmoore9@augusta.edu — Thu, 08 Aug 2019 05:55:24 GMT

Current State of the Art:Osteoporosis is treated with vitamins, exercise, and medications. Calcium and vitamin D taken on a regular basis has shown to help slow the progression of osteoporosis. The vitamins can be increased by altering diet and with supplements. Exercise that emphasizes weight bearing has been shown to be helpful. Actonel, Binosto, Boniva, and Fosamax work by slowing bone degeneration. Reclast is a new medication given as a once yearly to increase bone density and decrease fractures.Problems with the Current Art:None, or any mix, of the above treatments are 100% effective. Als...

Co-administration of NaHC03 and NH4Cl to reduce inflammation

mmoore9@augusta.edu — Mon, 06 May 2019 07:43:36 GMT

Co-administration of NaHC03 and NH4Cl to Reduce Inflammation Current state of the artThere are a number of anti-inflammatory drugs currently available on the market such as non-steroidal anti-inflammatory drugs (NSAIDS), corticosteroids, and disease modifying anti-rheumatic drugs (DMARDS). Problems with current state of artChronic use of non-steroidal anti-inflammatory drugs (“NSAIDS”), which inhibit the synthesis prostaglandins and thromboxanes, results in numerous undesirable side effects including an increased risk of stomach ulcers and heart attacks. Chronic use of co...

The use of EETs blocker or antagonists to enhance the efficacy of AT1 blocker to treat diabetic retinopathy.

mmoore9@augusta.edu — Wed, 08 Aug 2018 09:07:20 GMT

The use of EETs Blocker or Antagonists to Enhance the Efficacy of AT1 blocker to Treat Diabetic Retinopathy Application: Diabetic Retinopathy (DR) Advantages/Benefits: • This technology in combination with AT1 receptor blockade prevents and reduces DR • This technology can address the 33% of the U.S. population predicted to develop Diabetes by 2050 (most of those patients will develop DR) • This technology can be used in c...

The use of chemical compounds in treatment of metastatic cancer and in reducing the unwanted toxicities of chemotherapeutic agents when used in combination

mmoore9@augusta.edu — Wed, 08 Aug 2018 08:59:01 GMT

The use of chemical compounds in treatment of metastatic cancer and in reducing the unwanted toxicities of chemotherapeutic agents when used in combination Application: Chemotherapy Adjuvant Advantages/Benefits: • This technology eliminates cyclophosphamide-associated toxicities • This technology eradicates gMDSC-mediated cancer • This technology eradicates gMDSC-mediated metastasis Abstract: The global cancer drugs m...

Three-Dimensional Tumor Holder and Ruler in Live Mouse

mmoore9@augusta.edu — Wed, 08 Aug 2018 08:48:32 GMT

Current State of the Art: In preclinical studies, subcutaneous tumor volume is measured by calibers and other imaging systems such as CT, MRI, and ultrasonography to monitor tumor growth, disease progression, and response to treatments. The imaging system measure tumors in sedative animals in three dimensions. On the other hand, calibers measure two dimensions of the tumor, width and length. Problems with the Current Art Calibers measurement can be inaccurate because it treats tumors as a spherical shape and lacks height measurement. It is also prone to inter-operator erro...

Erbin as a Target to Regulate ErbB2 and Neuregulin Signaling

mmoore9@augusta.edu — Tue, 01 May 2018 13:01:17 GMT

AU researchers found that erbin is a protein that interacts with ErbB2 and is critical for its expression on the surface membrane. ErbB2 becomes unstable when erbin expression is inhibited by a small interference RNA. ErbB2 is one of the most potent oncogenes in tumor genesis and metastasis. This therapeutic agent competes favorably with other drugs used to disrupt ErbB2's function.

Use of 20-HETE blocker to eliminate stroke side effects and increase anti-tumor efficacy of rofecoxib (Vioxx) in colorectal cancer prevention

mmoore9@augusta.edu — Mon, 16 Apr 2018 14:27:59 GMT

Current State of the Art: Surgery, radiation, and chemotherapy are three primary modes of treatment available for colorectal cancer (CRC). Although different treatment options are available, the mortality rate in case of CRC is the second highest among other forms of cancer. Early detection and chemical prevention are two major strategies adopted to prevent CRC related deaths. Coxibs (selective cyclooxygenase-2 inhibitors) have been used to reduce CRC related inflammation and spread of the disease. Problem with the Current Art: Coxibs (rofecoxib and valdecoxib) showed significant recovery...

HSP90 inhibitor for cancer immunotherapy

mmoore9@augusta.edu — Mon, 12 Mar 2018 13:15:18 GMT

The current state of arts: Heat shock protein (Hsp) 90 inhibition is a potential mechanism for enhancing cancer immunotherapy. The problems with the current arts: However, none of the first-generation Hsp90 inhibitors and newly developed inhibitors have been FDA approved for cancer immunotherapy. It is urgent to identify an efficacious Hsp90 inhibitor that does not activate anti-apoptotic proteins. The advantage of our invention: AU researchers have identified the cyclohexadepsipeptide Enniatin A (EnnA), a natural compound as a novel inhibitor of Hsp90 chaperoning machine, bas...

Curcumin conjugates for the treatment of inflammation-associated disease

mmoore9@augusta.edu — Fri, 09 Mar 2018 11:36:52 GMT

The current state of the art: Inflammation is associated with many serious diseases, for example, rheumatoid arthritis, chronic hepatitis, myocardial infarction, brain ischemic injury, cancer, and pulmonary diseases. Anti-inflammatory drugs such as non-steroidal (including ibuprofen, naproxen, indomethacin, etc) and COX2 inhibitors have been in the market for a long time but they have various side effects including gastrointestinal ulceration, bleeding nephrotoxicity and serious side effects such as heart and renal failure. The problems with the current art: Novel anti-inflammatory active ...

Novel synergistic combinations for cancer therapy

mmoore9@augusta.edu — Thu, 08 Mar 2018 08:05:57 GMT

AU researchers have discovered several drug resistance genes that can be potentially used as therapeutic targets for cancer treatment. We also describe synergistic combinations between these genes and a large number of anticancer drugs that have been approved by the FDA for clinical use or clinical trials. Therefore, these genes alone or in combination with existing drugs can offer more efficient treatment for cancer.

Novel Composition for HER2+ Cancer

mmoore9@augusta.edu — Thu, 11 May 2017 11:46:59 GMT

The Current State of the Art: HER2 (also known as ErbB2), a receptor tyrosine kinase is overexpressed in around 25% of breast cancer cells. It is a known anti-cancer target to the monoclonal antibody, Trastuzumab. Limitation of the Current Art: However, about 20% patients develop resistance to Trastuzumab. Pertuzumab, Lapatinib, and other trastuzumab conjugates are being developed to overcome drug resistance. But cancer cells still escape from these treatments via intrinsic or de novo pathways. It is critical to identify new pathways to expand the treatment options for HER2+ cancer. ...

Composition and Use of Nitration Shielding Peptides in Diseases with Elevated Protein Nitration

mmoore9@augusta.edu — Thu, 20 Aug 2015 12:37:02 GMT

Title Composition and Use of Nitration Shielding Peptides in Diseases with Elevated Protein Nitration Current State of the Art Elevated nitration of proteins is associated with different diseases and disorders such as acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Effective inhibition of nitration of proteins is an active area of research for drug discoverers. Problems with the Current Art Current methods of treating protein nitration and the myriad of pathologies associated therewith are insufficient. Advantage of the Inventio...

Portable and Non-invasive Device for the Diagnosis of Traumatic Brain Injuries

mmoore9@augusta.edu — Tue, 21 Jul 2015 13:01:00 GMT

Present State of the Art Mild traumatic brain injuries (TBI) or concussions are diagnosed by neuropsychological tests to evaluate the cognitive functioning and basic sensory-motor processes. Problem with the Current Art Neuropsychological testing is a lengthy and complex process, and is not typically performed immediately after the occurrence of the injury. Advantage of Present Art Researchers at Augusta University developed a system and device to measure subtle structural changes (surface feature and segmental volume) in the optic nerve sheath that are...

Tissue Chip Bioreactor for Tissue Engineering

mmoore9@augusta.edu — Mon, 20 Jul 2015 05:28:07 GMT

Researchers at AU developed a full-scale prototype of a bioreactor for growing complex tissues in a scalable manner. This bioreactor chip can yield several mm tissues consisting of different cell types. Apart from tissue transplants it can also be used for high-throughput tissue engineering and pre-clinical replacement for animal models.

Protective Effects of Curcumin Against Hemorrhagic Stroke Injury

mmoore9@augusta.edu — Wed, 23 Apr 2014 11:28:23 GMT

Presented here are compounds, compositions and methods for preventing and treating diseases such as intracerebral hemorrhage, cancer, or conditions associated with damaged cells, activated lymphocytes, or microbial products. The compounds are curcumin analogs. It is an object of this invention to provide compounds and compositions that have greater systemic bioavailability than curcumin and to provide compounds, compositions and methods that treat intracerebral hemorrhage. The invention is also aimed to prevent and treat malignant gliomas and treatment of diseases or conditions associate...

Novel Analogs of Choline for Neuroprotection and Cognitive Enhancement in Neurodegenerative Disorders

mmoore9@augusta.edu — Wed, 14 Nov 2012 05:31:17 GMT

Current State of the Art: Acetylcholine neurotransmission in the peripheral and central nervous system is responsible for autonomic function (heart beating, breathing) and cognitive skills including working memory, muscle. Degeneration of the nervous system and/or cognitive dysfunction/impairment are associated with a variety of neurological diseases and disorders including but not limited to Senile Dementia, Schizophrenia, Alzheimer’s, Parkinson’s and Huntington’s Disease. Top competitors on the market that target acetylcholine neurotransmission are the Alzheimer’s Di...

Netrin-1 as a Potential Target for Diagnosis and Treatment of Male Fertility and Infertility Associated Disorders

mmoore9@augusta.edu — Tue, 06 Sep 2011 08:21:05 GMT

Current State of the Art Male infertility can range from low or no production of sperm to poor motility in mature sperm. Treatments for male infertility include surgery that can involve removing occlusions that block sperm motility or direct harvesting of the sperm. Medications are used that increase sperm production. These include gonadotropins, testosterone and anti-estrogen fertility drugs like tamoxifen (Nolvadex), clomiphene (Clomid) and bromocriptine. The only contraceptive choices available for male reproductive decisions are prophylactics, vasectomy and abstinence. Hormonally based ...

A Mouse Model for Neurodegenerative Disorders

mmoore9@augusta.edu — Tue, 06 Sep 2011 08:02:39 GMT

Model for Alzheimers Disease · Vps35 mutant · Increased amyloid and tau pathologies · Defects in: o Spatial learning and memory o Long term potentiation o Glutaminergic transmission · Inventor: Wen-Cheng Xiong, PhD; Lin Mei, PhD Case Number: GHSU 2012-008 Material Transfer Agreements for Profit and Not-For Profit Entities are availab...