Latest technologies from Georgia Health Sciences Universityhttp://augustaoic.technologypublisher.comBe the first to know about the latest inventions and technologies available from Augusta Universityen-USSun, 18 Mar 2018 02:21:11 GMTMon, 12 Mar 2018 13:15:18 GMT 2018, Georgia Health Sciences UniversityEnniatin A as a Novel Hsp90 Machine Inhibitor Combining Cancer Cell Toxicity and Immunotherapy researchers have developed a unique high throughput screen (HTS) based on the progesterone receptor (PR) and the five components of the Hsp90 machine. During their preliminary screening of natural products , they discovered that the cyclic peptide Enniatin A (EnnA) kills cancer cells through inhibition of the Hsp90 machine without a significant induction of HSR. In addition, EnnA induces a powerful T cell-mediated immune response, resulting in highly efficient tumor killing in a syngeneic mouse model and long-term memory against the primary tumor. At the molecular level, EnnA reduces the pr...Mon, 12 Mar 2018 13:15:18 GMTCACLARK@augusta.edu or Allogeneic Mesenchymal Stem Cell Therapy for Premature Ovarian Failure and other forms of ovarian-based female infertility ovarian failure (POP) is defined as hypergonadotropic ovarian failure occurring prior to age 40. AU researchers used human bone marrow mesenchymal stem cells to reverse infertility in a chemotherapy induced ovarian failure mouse model. The cells were delivered by direct intra-ovarian injection. The treatment were successful with all treated mice achieving viable pregnancy and producing pups, overall the number of pups were about 30% compared to that achieved by healthy controls. All delivered pups appeared with normal morphology with no apparent anomalies or abnormalities. They were ...Fri, 09 Mar 2018 12:08:41 GMTCACLARK@augusta.edu of the p53 pathway as a novel target for cancer immunotherapy researchers have identified a novel population of immunogenic dendritic cells that arise from rapid transdifferentiation of immature myeloid-derived suppressor ceils (MOSCs) in tumors. We have discovered that this DC trans-differentiation step is driven by p53 expressed by the host (not the tumor). Mice with a deletion of p53 in host cells lose exactly this Ly6c+CD103+ DC population (and no others), and they become selectively unable to respond to all forms of anti-tumor immunotherapy that we have tested. Conversely (and with major implications for clinical immunotherapy) if we artificially...Fri, 09 Mar 2018 11:45:18 GMTCACLARK@augusta.edu Conjugates as Potential Pharmacophore anti-inflammatory properties of the synthesized curcumin-amino acid conjugates were determined by the standard method of acute carrageenan induced paw edema in rats. From the results obtained synthesized conjugates exhibited promising anti-inflammatory properties with potency higher than that of indomethacin (standard reference used exhibiting higher potency than that of ibuprofen). Fri, 09 Mar 2018 11:36:52 GMTCACLARK@augusta.edu targeting of CD44 and EpCAM with a bispecific aptamer effectively inhibits intraperitoneal ovarian cancer growth researchers developed an RNA-based bispecific CD44-EpCAM aptamer that is capable of blocking CD44 and EpCAM simultaneously by fusing single CD44 and EpCAM aptamers with a double stranded RNA linker. With the aid of a panel of ovarian cancer cell lines, we found that bispecific CD44-EpCAM aptamer was much more effective than either single CD44 or EpCAM aptamer in the ability to inhibit cell growth and to induce apoptosis. When these aptamers were tested in intraperitoneal ovarian cancer xenograft model, bispecific CD44-EpCAM aptamer suppressed intraperitoneal tumor outgrowth much more signif...Thu, 08 Mar 2018 10:04:37 GMTCACLARK@augusta.edu Molecule Histone Methyltransferase SUV39H1 Inhibitor F5446 researchers have invented F5446 which represents the first small molecule SUV39H1 inhibitor that can be chemically synthesized and is safe in vivo. We envision the following use of F5446: 1) an effective SUV39H1 inhibitor as a research reagent; 2) monotherapy for human cancer therapy, particularly for advanced human colorectal cancer; and 3) as a potentiating agent for anti-PD-1/PD-L1 immunotherapy.Thu, 08 Mar 2018 08:14:38 GMTCACLARK@augusta.edu synergistic combinations for cancer therapy researchers have discovered several drug resistance genes that can be potentially used as therapeutic targets for cancer treatment. We also describe synergistic combinations between these genes and a large number of anticancer drugs that have been approved by the FDA for clinical use or clinical trials. Therefore, these genes alone or in combination with existing drugs can offer more efficient treatment for cancer.Thu, 08 Mar 2018 08:05:57 GMTCACLARK@augusta.edu EGFR/HER@/HER3 with a three-in-one aptamer-siRNA chimera researchers have developed a three-in-one nucleic acid aptamer-siRNA chimera, which targets on EGFR/HER2/HER3 in one molecule. This inhibitory molecule was constructed such that a single EGFR siRNA is positioned between HER2 and HER3 aptamers to create a HER2 aptamer-EGFR siRNA-HER3 aptamer chimera (H2EH3). EGFR siRNA was delivered into HER2 expressing cells by HER2/HER3 aptamers-induced internalization. HER2/HER3 aptamers act as antagonist molecules for blocking HER2 and HER3 signaling pathways and also as tumor targeting agents for siRNA delivery. H2EH3 enables down-modulation of the expr...Thu, 08 Mar 2018 07:51:29 GMTCACLARK@augusta.edu Compositions and Methods for Inhibiting Endospores Using Green Tea Polyphenols, 15 Aug 2017 12:00:36 GMTCACLARK@augusta.edu proteins to RBCs (protein-RBCs) with EDC can be improved with sulfo-NHS +/- sulfo-NHS-acetate, 08 Jun 2017 16:18:16 GMTCACLARK@augusta.edu Target and New Breast Cancer Drugs for Chemo-Resistant Tumors, 11 May 2017 11:46:59 GMTCACLARK@augusta.edu EGFR and survivin with a bivalent aptamer-dual siRNA chimera effectively suppresses prostate cancer, 09 Jan 2017 11:48:48 GMTCACLARK@augusta.edu Potential colon cancer drugs with increased efficacy and lower side effects., 18 Oct 2016 11:08:31 GMTCACLARK@augusta.edu of Cationic Polymer Polyethylenimine (PEI) to Induce Indoleamine 2,3 Dioxygenase (IDO) as a Means to Control Adaptive Immune Responses current invention teaches the systemic treatment with a standard commercial polyethylenimine (PEl) preparation mixed with bacterial plasmid DNA (PEI/pDNA complexes or 'nanoparticles') induced endogenous expression of the enzyme indoleamine 2,3 dioxygenase (IDO) in lungs and lymph nodes (LNs) of treated mice. IDO induction in these tissues was detected by RT-PCR to detect IDO RNA, and HPLC analysis to detect the amino acid tryptophan (Trp, an IDO substrate) and kynurenine (Kyn, a tryptophan catabolite produced by cells expressing IDO). We have previously shown (and patented) that IDO is a p...Tue, 13 Oct 2015 16:55:13 GMTCACLARK@augusta.edu transgenic lymphoma mouse model and therapeutic strategies, 13 Oct 2015 16:54:43 GMTCACLARK@augusta.edu Parametric Mapping Method for Correction of Noise-based Systematic Bias of DTI Metrics, Using a DTI Mapping Phantom invention describes the apparatus and data processing technique for correcting the noise based systematic bias within MRI diffusion tensor image (DTI) sequences. The specific claim requested in this IP document is for coverage of 1) the phantom design, 2) the concept of the parametric remapping technique, and 3) the use of the phantom to determine the parametric map. During a DTI sequence, a series of images is generated by applying gradient magnetic fields along particular directions, to measure the amount of diffusion of water within tissues in those same directions (or whatever may be ...Tue, 13 Oct 2015 16:54:14 GMTCACLARK@augusta.edu receptor targeted and virus-like particle (VLP) based tripartite chimeric vaccine technology ID 2012-025 Title: Tripartitie Polypeptide Vaccine Vector Current State of the Art: Although traditionally viewed as an anti-infectious preventive measure, vaccine use has expanded to treating non-infectious diseases including cancer. Provenge (Dendreon) is currently the only FDA approved therapeutic vaccine at approximately $95,000 per treatment. Therapeutic vaccines in clinical trials are targeting glioblastoma, cervical, skin, head, neck, pancreatic, breast and lung cancer; as well as celiac disease and recurrent yeast infections from companies like GlaxoSmithkline, Rxi Pharmaceuticals...Tue, 13 Oct 2015 16:52:56 GMTCACLARK@augusta.edu Shielding Peptides and Methods for Inhibiting Nitration of Proteins, 20 Aug 2015 12:37:02 GMTCACLARK@augusta.edu Hsp90 Inhibitors for Breast Cancer Treatment, 06 Aug 2015 06:14:31 GMTCACLARK@augusta.edu Therapeutic for Breast and Prostate Cancer Treatments, 30 Jul 2015 07:06:54 GMTCACLARK@augusta.edu Portable and Non-invasive Device for the Diagnosis of Traumatic Brain Injuries, 21 Jul 2015 13:01:00 GMTCACLARK@augusta.edu Bioreactor for Multilayered Tissues Consisting of Different Cell Types, 20 Jul 2015 05:28:07 GMTCACLARK@augusta.edu Agonists Based Therapeutics, 17 Jul 2015 11:43:54 GMTCACLARK@augusta.edu A, Therapeutic Agent for Colon Cancer and Leukemia, 13 Jul 2015 08:36:59 GMTCACLARK@augusta.edu A Vaccine Therapeutic for Treatment of Cervical Cancer, 13 Jul 2015 07:54:04 GMTCACLARK@augusta.edu for Therapeutic Monitoring of Ovarian Cancer method for assessing therapeutic outcome of a treatment for ovarian cancer comprising determining the amount of one or more proteins in a blood sample from a ovarian cancer patient who is at remission after treatment, wherein the one or more proteins are selected from the group consisting of siCAM1, sTNFR-II, RANTES, sgpl30, MMP-2, CA15-3, MIG, sVCAM-1, TPO, sTNFR-I and MDC and combinations thereof, and wherein elevated serum amounts of the one or more proteins or reduced level of MDC relative to a control indicates that the subject has poor overall survival relative to subjects in remission...Wed, 21 May 2014 07:29:15 GMTCACLARK@augusta.edu Effects of Curcumin Against Hemorrhagic Stroke Injury, 23 Apr 2014 11:28:23 GMTCACLARK@augusta.edu,+ as a Drug Target for the Treatment of Cancer, Inflammation, and Ulcerative Colitis, 31 Dec 2013 08:08:47 GMTCACLARK@augusta.edu of Novel Gradient Directions with Diffusion to MRI to Synthesize Complex Diffusive Geometrics invention provides a phantom, or a test object, which includes anisotropic structures, which can be used to monitor DTI measures. The anisotropic structures include a plurality of water-filled capillaries, arranged in a predefined configuration. In addition to using the phantom for providing quality assurance (QA) measurements of DTI in a conventional manner, data scanned using a phantom of the present invention having simple, prolate geometry can be employed to synthesize ADC distributions that exhibit complicated behavior. The method of the present invention may be used for studying ana...Fri, 27 Dec 2013 05:55:28 GMTCACLARK@augusta.edu of Image Intensities with Diffusion MRI to Synthesize Complex Diffusive Geometries invention is composed of a phantom and DTI bench marking that allows DTI to proceed, applicable to tissue structures found throughout the body. Bench marking of DTI data will allow for a host of benefits, including 1) appropriate comparison of DTI data within multi-center trials; 2) appropriate ranges of uncertainty that could be presented with an examination, to improve the characterizing of tissue (for example, tumor demarcation, white matter infiltration) for pre-surgical planning; 3) characterization of MR scanner performance over time at an institution, for maintenance decisions; 4) ...Fri, 27 Dec 2013 05:20:45 GMTCACLARK@augusta.edu of K-space Data with Two Different Applied Diffusion Gradients with DTI MRI, To Synthesize Complex Diffusive Geometrics, 26 Dec 2013 09:34:16 GMTCACLARK@augusta.edu for Successful Aging Without Cognitive Decline Biomarker for Successful Aging without Cognitive DeclineCurrent State of the Art: It is estimated that up to one third of adults will experience a gradual decline in cognitive function known as mild cognitive impairment as they age. Individuals with cognitive decline are able to function reasonably well in everyday activities, such as managing finances and purchasing items at stores without assistance, but have difficulty remembering details of conversations, events and upcoming appointments. Most (but not all) patients with cognitive decline develop a progressive decline in their think...Mon, 23 Dec 2013 07:26:13 GMTCACLARK@augusta.edu Vivo Delivery and Removal of Metals, 16 Dec 2013 05:50:48 GMTCACLARK@augusta.edu paragloboside regulation in inflammation: use of siRNA and/or antisense oligonucleotide as anti-inflammatories, 16 Dec 2013 05:12:03 GMTCACLARK@augusta.edu Delivery Method for a Gene Correction Reagent in Mammalian Cells Including Hematopoietic and Other Stem Cells State of the Art:Gene therapy involves the use of introducing healthy genes into a patient whose own genes are defective.  In theory, the genes introduced will combine with the patient’s DNA in targeted cells to trigger production of healthy cells.  Gene therapy has become a viable medical treatment option for certain diseases.  Many current gene therapies use foreign DNA or viral vectors.  Applications exist for oncology, cystic fibrosis, Parkinson’s disease, Huntingon’s disease, retinal degeneration, pancreatitis, AIDS and sensory disorders such as loss of sight and sound.    Problem...Thu, 03 Oct 2013 07:37:58 GMTCACLARK@augusta.edu Metabolite Mimetics Synthesis and Use in Cancer Therapy, 03 Oct 2013 07:30:49 GMTCACLARK@augusta.edu of an Endothelial Nitric Oxide Synthase Mutant Resistant to Inhibition by Oxidative Stress for the Treatment of Endothelial Dysfunction State of the Art:A major complication of vascular disease is endothelial dysfunction caused by oxidative stress to the vasculature.  Treatment options include surgery, implantation of stints, medications and lifestyle changes.  Currently there are no gene therapy treatments available for endothelial dysfunction.  Available chemical and pharmaceutical treatments do not work on a cellular level, though research is underway to study the molecular biology of this mechanism. The biochemistry of cellular oxidative stress links nitric oxide (NO) to endothelial function, which is why various e...Thu, 03 Oct 2013 05:29:30 GMTCACLARK@augusta.edu of Short-Chain Fatty Acids for Treatment of Intestinal Disorders and Colon Cancer, 26 Jul 2013 08:08:11 GMTCACLARK@augusta.edu Antagonists Prevent Pulmonary Oxygen Toxicity State of the ArtPulmonary oxygen toxicity is a condition resulting from the harmful effects of breathing molecular oxygen at elevated partial pressures. Oxygen toxicity is a concern for scuba divers, those on high concentrations of supplemental oxygen (particularly premature babies), and those undergoing hyperbaric oxygen therapy.  Problems with the Current ArtSupplemental oxygen in premature infants contributes to the development of bronchopulmonary dysplasia (BPD), and high-pressure oxygen delivery in general results in necrotizing bronchiolitis and alveolar septal injury. Currently,...Wed, 27 Mar 2013 08:14:30 GMTCACLARK@augusta.edu and System for Measuring Dynamic Changes of Cardiac Pulse and Respiration Throughout Day/Night Cycle  TitleLight-Independent Measuring Dynamic Changes of Cardiac Pulse and Respiration Current State of the ArtBreathing or pulse monitoring of a baby in danger of Sudden Infant Death Syndrome (SIDS) or a sleep apnea patient typically employs a camera system (e.g., Close View Monitor System) or a movement/sound system (e.g., Angelcare Movement Sensor w. Sound Monitor).   Problems with the Current ArtThe problem with these systems is that they require constant attention by another person.  Advantages of InventionThe invention presented here relates to the rapid measurement of physiological paramet...Tue, 26 Mar 2013 12:55:46 GMTCACLARK@augusta.edu Detection of Peptide Fragments Specific to Galectin-3 for the Detection and Monitoring of Well-differentiated Thyroid Cancer, Head and Neck Cancer, Lung Cancer, Colorectal Cancer and Other Cancers and Disease States, 15 Feb 2013 11:11:17 GMTCACLARK@augusta.edu of Peptide Mimics of GM1 Ganglioside: A Prophylactic for Cholera ID: 2012-004 Title: Peptide Mimics for Treatment of GM-1 Associated Diseases Including Cholera and Guillain-Barre SyndromeCurrent State of the Art: Ganglioside GM1-associated diseases or infections are prevalent worldwide, and hundreds of millions of people are infected, or diagnosed, with ganglioside GM1-associated diseases each year. Exemplary diseases or disorders involving GM1 include, but are not limited to cholera, Guillain–Barré Syndrome (GBS), lupus, and enterotoxigenic Escherichia coli (ETEC) infection. Problems in the Current Art: Existing treatments for disorders involving GM1 ...Mon, 11 Feb 2013 09:30:52 GMTCACLARK@augusta.edu and Prevention of Age-Related Muscle Wasting (Sarcopenia) TECH ID: 2010-029 Title: Leptin and derivatives for altering muscle mass Current State of the Art: Muscling wasting is the progressive loss of muscle mass, typically seen in the elderly (sarcopenia), in individuals on low calorie diets and or struggling with a serious illness including cancer (Cachexia). This excessive loss of muscle can lead to fragility, unsteadiness and an increase in body fat.  Disadvantages of the Art: Lifestyle recommendations, dietary supplements and hormone replacement therapies perform poorly and in the case of the latter are expensive and have potentially life threa...Wed, 16 Jan 2013 07:30:11 GMTCACLARK@augusta.edu and Its Derivatives as Anti-Cancer Drugs IDs: 2007-020/2009-038 Title: ATBo+ as a target of Alpha-Methyl_L_Tryptophan and Its Derivatives, as Anti-Cancer Drugs and as Inhibitors of Indoleamine Dioxygenase.Current State of the Art: ATBo+, an amino acid transporter, is elevated in some breast, cervical and colon cancer cells and in intestine epithelial cells. In vivo data also support inhibition of ATBo+ function as a treatment of inflammatory bowel disease.  Disadvantages with the Current Art: Few drugs can kill the cancerous cells without adversely affecting the overall health and quality of life of the patient. Targeting thera...Wed, 16 Jan 2013 07:24:09 GMTCACLARK@augusta.edu Apparatus for Cutting Tissue Single surgical instrument uses unique design for cutting membranes covering tissue. Current State of the Art: There are several surgical procedures that require the cutting and re-positioning of a membrane in order to access the underlying tissues. These include but are not limited to the dura mater of the brain and spinal cord. To perform these procedures surgeons need surgical grade instruments that allow them to cut a slit in the membrane, hold the membrane up and support and separate the membrane from the underlying tissue, as the surgeon re-positions and continues to cut a...Mon, 14 Jan 2013 10:19:17 GMTCACLARK@augusta.edu of Novel Therapies for Experimental Guillain-Barre Syndrome Using Ganglioside-Like Phage-Peptide, 11 Jan 2013 05:09:29 GMTCACLARK@augusta.edu Specific Expression in Transgenic Zebrafish, 09 Jan 2013 12:29:35 GMTCACLARK@augusta.edu Mouse Model for Mental Disorders and Epilepsy State of the Art The Neuregulin/ErbB4 signaling pathway is involved in GABAergic neurotransmission, an important inhibitory neurotransmission that regulates several processes in the central nervous system including muscle tone. Aberrant GABAergic function has been implicated in Schizophrenia, Schizo-affective disorder and in Epilepsy. Clinically overlap has been observed in the development of Schizophrenia, Schizo-affective Disorder and Epilepsy. In some cases treatments for one disorder can cause symptoms of the other. This implies common pathways intertwine in the developme...Wed, 09 Jan 2013 12:22:47 GMTCACLARK@augusta.edu Tech has lead - Microirradiator for Treatment of Skin Tumors State of the Art: The incidence of cancer is rising worldwide, with more than 11 million cases recorded annually. Incidence is expected to increase further, driven by rising life expectancy rates and aging global population. This is expected to increase the demand in the radiation therapy market which is currently experiencing technological advancements leading to more effective therapy that is precise and commercially viable. Highly accurate and targeted radiation therapy has the potential to replace surgery, driving the demand for radiation therapy equipment to over $3.6 bi...Thu, 06 Dec 2012 05:11:40 GMTCACLARK@augusta.edu Novel SUMO-like Gene for Type 1 Diabetes Susceptibility, 14 Nov 2012 05:34:06 GMTCACLARK@augusta.edu Method for Multiple Site-Directed Mutagenesis of More than 10 Sites State of the Art: Being able to genetically manipulate a living system is an essential tool in understanding how living systems work. Site directed mutagenesis strategies allow researchers to change DNA sequences to determine how this will influence the function of a protein or important DNA regulatory element. Site-Directed mutagenesis strategies are used globally in almost any laboratory interested in manipulating genetics or protein function; or for engineering biological materials. The life sciences research tools market was estimated at $42 billion in 2010. Reagents and ...Wed, 14 Nov 2012 05:33:26 GMTCACLARK@augusta.edu Analogs of Choline for Neuroprotection and Cognitive Enhancement in Neurodegenerative Disorders, 14 Nov 2012 05:31:17 GMTCACLARK@augusta.edu Plays a Critical Role in Tau Hyperphosphorylation and Tauopathies (e.g., Alzheimer’s Disease, ALS, Parkinson’s, and Others) of the Art:Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), are considered to be protein misfolding disorders. Heat shock proteins provide a line of defense against protein misfolding disorders and are among the most potent suppressors of neurodegeneration in animal models. Several different heat shock proteins are implicated in the misfolding associated with the fore-mentioned diseases.  Problem with the Current Art:Alzheimer's therapeutics have thus far failed to provide an effective treatment. There are no therapeutics available for Parkinson's Diseas...Tue, 13 Nov 2012 11:35:48 GMTCACLARK@augusta.edu of Polyanions to Remineralize Demineralized Dental Hard Tissues, 13 Nov 2012 10:05:56 GMTCACLARK@augusta.edu of Dioleoylphosphatidylglycerol (DOPG) to Accelerate Corneal Wound Healing State of the Art: Corneal abrasions are typically allowed to self heal despite the discomfort and potential risk of infection. Lubricants, antibiotics and in severe cases eye patches are provided in an attempt to avoid contact with the eye as patients experience pain and discomfort while waiting for the long process of healing. These methods are also employed for post-operative procedures, again to alleviate irritation and pain during the healing process.Lubricants and eye patches are provided over the counter (OTC) while antibiotics require a prescription. Industry leaders in providin...Mon, 12 Nov 2012 12:19:39 GMTCACLARK@augusta.edu of an Orthodontic Bracket Placement Device and Coordinated Bracket Placement System Title: Orthodontic Bracket Placement Device and Coordinated Bracket Placement System Current State of the Art: Orthodontic brackets are used by general dentists and orthodontists throughout the world. The proper placement of these brackets is essential for eventual correction of poorly aligned teeth in both children and adults. In order to guide tooth movement during orthodontic treatment, orthodontic brackets are placed at precise vertical positions on the teeth. Disadvantages with the Current Art: The difficultly in accurately placing orthodontic brackets for proper guidance of to...Mon, 12 Nov 2012 12:16:53 GMTCACLARK@augusta.edu Promoter Specifically Active in Newly Forming and Remodeling Arteries, 07 Nov 2012 14:16:12 GMTCACLARK@augusta.edu of Integrating Sphere Technology To Provide Uniform, High-intensity Light and Wavelength Mixing from Light Emitting Diodes, 07 Nov 2012 14:11:51 GMTCACLARK@augusta.edu and Apparatus for Light-Curing Resin Adhesives for Orthodontics Brackets, 07 Nov 2012 14:09:16 GMTCACLARK@augusta.edu Acid Derivatives as Therapy for Renal and Cardiovascular Diseases Epoxy Lipid Mimics as Lead Compounds for Endothelial Dysfunction Current State of the Art:  Endothelial cell dysfunction is an underlying cause of vascular disease and is also found in patients with coronary artery disease, diabetes, high cholesterol and high blood pressure (hypertension). Available treatments include nonsteroidal anti-inflammatory drugs (NSAIDS), angiotensin receptor blockers (ARB) and ACE (angiotensin converting enzyme) inhibitors. The NSAIDS target enzymes that metabolize arachidonic acid. These metabolites regulate angiotensin II function and subsequently endothelia...Wed, 07 Nov 2012 14:08:26 GMTCACLARK@augusta.edu Ligands as Anti-Cancer and Anti-Diarrheal Drugs ID: 2007-030: Compositions Comprising a GPR109 Ligand for Treating Disorders of the Digestive Tract and/or CancerState of the Art: Top drugs for colon cancer include Xeloda (Genetech), Erbitux (Johnson and Johnson), Eloxatin (Sanofi), and Gleevec (Novartis). These four drugs ranked in the top 10 selling cancer drugs of 2011 and totaled ~$4 billion out of $12.4 billion in total sales.Problems in the Art: Of the above listed best sellers, several have been on the market since 2002 or earlier and in some cases are close to the end of patent protection. Advantages of the Invention: This inven...Wed, 07 Nov 2012 14:07:08 GMTCACLARK@augusta.edu of H295R Adrenal Cancer Cell Clones as Potentially Improved Cell Culture Model Systems to Study Steroidogenesis  Human Adrenal Carcinoma Cell Line Clones: Improved Models for Steroidogenesis.  Current State of the Art: Steroidogenesis is the production of hormones from cholesterol including aldosterone (regulates potassium in the blood) and corticosteroids (stress reponse). These hormones are primarily produced in the adrenal gland. Diseases and disorders of steroidogenesis in the adrenal glands include primary aldosteronism (PA). PA is the most common form of hormonally induced hypertension affecting ~8-10% of hypertensive subjects. Cell culture model systems offer a rapid and easily malleable a...Wed, 07 Nov 2012 07:40:15 GMTCACLARK@augusta.edu as a Potential Target for Diagnosis and Treatment of Male Fertility and Infertility Associated Disorders State of the ArtMale infertility can range from low or no production of sperm to poor motility in mature sperm. Treatments for male infertility include surgery that can involve removing occlusions that block sperm motility or direct harvesting of the sperm. Medications are used that increase sperm production. These include gonadotropins, testosterone and anti-estrogen fertility drugs like tamoxifen (Nolvadex), clomiphene (Clomid) and bromocriptine.The only contraceptive choices available for male reproductive decisions are prophylactics, vasectomy and abstinence. Hormonally based contr...Tue, 06 Sep 2011 08:21:05 GMTCACLARK@augusta.edu Mouse Model for Neurodegenerative Disorders, 06 Sep 2011 08:02:39 GMTCACLARK@augusta.edu has lead - Communication and Skills Training Using Interactive Virtual Humans, 08 Aug 2011 07:26:36 GMTCACLARK@augusta.edu Peptide Modulators of Delta Protein Kinase C Interaction with the d-subunit of F1Fo ATP Synthase/ATPase as Therapeutics Against Cardiac Injury, 26 Jul 2011 10:08:47 GMTCACLARK@augusta.edu Adeninedinucleotide (beta-NAD) Protects and Repairs the Pulmonary Endothelial Cell Barrier in Acute Lung Injury and Acute Respiratory Distress Syndrome and Improves Mortality in Sepsis, 26 Jul 2011 08:21:49 GMTCACLARK@augusta.edu of JNK Signaling and JNK Inhibitors for the Treatment of Spinal Muscular Atrophy, 26 Jul 2011 08:21:36 GMTCACLARK@augusta.edu