Sulfoglucuronosyl paragloboside regulation in inflammation: use of siRNA and/or antisense oligonucleotide as anti-inflammatories


TECH ID 2011-028 Title: Methods and Compositions for Maintaining Blood-Brain Barrier Integrity

Current State of the Art: The BBB tightly regulates access to the brain that prevents large molecule therapy transport. Certain infections and disorders would benefit from allowing controlled access of therapeutics across the BBB including but not limited to Cancer, Meningitis, Rabies and De Vivo Disease (poor transport of glucose across the BBB). HIV Encephalitis, Alzheimer’s, Epilepsy and MS exhibit signs of a leaky BBB that could benefit from maintaining BBB integrity.

Problems with the Art:  The most promising technologies targeting BBB requires the use of recombinant technology which highly limits the use of currently available therapeutics. 

Advantage of the Invention: The invention describes compositions and methods for controlling blood brain barrier integrity by increasing resistance to pathological molecules including but not limited to cytokines, pathogens, immunoglobins, bio-degrading molecules and apoptotic factors, either as a result of a genetic disorder or exposure to pathogens or toxins. Could also be used to regulate BBB integrity when access through this barrier is beneficial.


Patent Information:
For Information, Contact:
Augusta University
Robert Yu
Somsankar Dasgupta
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