Effect of Green Tea Polyphenols on Autoimmune Disorders: A Novel Approach Involving Inhibition of Autoantigen Expression, Inflammation and Apoptosis


Present State of the Art:

Each year, autoimmune and chronic inflammatory diseases affect millions of people worldwide; and the incidence rates are trending upward.  Accepted clinical interventions include, NSAIDS, steroids, genetic alteration of inflammatory molecule receptors and therapeutic antibodies; but presently, there are no effective cures. Toxicity and cost are a significant downside of these protocols.  Green Tea Polyphenols (GTPs) have been shown to be anti-apoptotic and inhibit inflammation. Additionally, clinical trial data suggests that constant consumption of polyphenols is protective against cardiovascular and neurodegenerative diseases.


Problem with the Current Art:

Standard autoimmune and inflammatory disease therapies can be toxic and immunosuppressive.


Advantage of Present Art:

Augusta University researcher’s novel finding that the most abundant GTPs potently inhibit autoantigen expression in keratinocytes and salivary gland cells portends a more cost effective and less toxic alternative for addressing the symptoms of autoimmunity and inflammation. Dietary supplementation of epigallocatechin-3-gallate (EGCG) could safely and inexpensively address the autoantibody production, inflammation and apoptosis in affected tissues associated with these conditions.


Patent Information:
Medical Devices
For Information, Contact:
Carl Clark
Director Technology Transfer
Augusta University
Stephen Hsu
Carol Lapp
George Schuster
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