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Use of Cationic Polymer Polyethylenimine (PEI) to Induce Indoleamine 2,3 Dioxygenase (IDO) as a Means to Control Adaptive Immune Responses
The current invention teaches the systemic treatment with a standard commercial polyethylenimine (PEl) preparation mixed with bacterial plasmid DNA (PEI/pDNA complexes or 'nanoparticles') induced endogenous expression of the enzyme indoleamine 2,3 dioxygenase (IDO) in lungs and lymph nodes (LNs) of treated mice. IDO induction in these tissues was d...
Published: 8/13/2019   |   Inventor(s): Andrew Mellor, David Munn, Lei Huang, Madhav Sharma
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Category(s): Therapeutics
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