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Manipulation of the p53 pathway as a novel target for cancer immunotherapy

AU researchers have identified a novel population of immunogenic dendritic cells that arise from rapid transdifferentiation of immature myeloid-derived suppressor ceils (MOSCs) in tumors. We have discovered that this DC trans-differentiation step is driven by p53 expressed by the host (not the tumor). Mice with a deletion of p53 in host cells lose exactly...

Published: 4/7/2023 | Inventor(s): David Munn

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Category(s): Therapeutics