Novel Analogs of Choline for Neuroprotection and Cognitive Enhancement in Neurodegenerative Disorders


Current State of the Art:

Acetylcholine neurotransmission in the peripheral and central nervous system is responsible for autonomic function (heart beating, breathing) and cognitive skills including working memory, muscle. Degeneration of the nervous system and/or cognitive dysfunction/impairment  are associated with a variety of neurological diseases and disorders including but not limited to Senile Dementia, Schizophrenia, Alzheimer’s, Parkinson’s and Huntington’s Disease.


Top competitors on the market that target acetylcholine neurotransmission are the Alzheimer’s Disease therapeutics including Donepezil (Aricept), Galantamine (Razadyne) and Rivastigmine (Exelon).


Disadvantages with the Current Art:

Many of the therapeutics for neurodegenerative disorders can only treat the symptoms of the disease while failing to slow down the progression of the disease. In some cases, many patients do not respond to current therapies. What is needed are therapeutics that can treat the cognitive impairment associated with neurodegenerative diseases and slow or halt the progression of the disease.


Advantages of Invention: 

A library of tertiary amine analogs of choline were developed and screened for utility as therapeutic agents for neurological and neurodegenerative diseases and disorders. Two compounds have been evaluated for the treatment of cognitive dysfunction/impairment that were also found to have neuroprotective benefits.

In rodent and simian studies these analogs improved cognition and working memory in a dose dependent manner.


Patent Status: US Patent Issued 6,881,738 (2002) and 7,786,147 (Divisional; 2010); Non-Provisional (Divisional) filed US2010/0324064


Inventor(s):  J.J. Buccafusco, A.V. Terry, J.W. Beach, R.R. Jonnala


Case Number: GHSU 2000-007

Patent Information:
For Information, Contact:
Ghsu Admin
Augusta University
Jerry Buccafusco
Alvin Terry, Jr.
J. Warren Beach
Ramamohana Jonnala
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