Search Results - Therapeutics

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Antibody specific for PKG-1alpha nitration
Scientists at AU identified that nitration of PKG-1α in tyrosine 247 attenuates the catalytic activity of PKG-1 α, which plays a critical role in the development of vascular dysfunction in pulmonary hypertension and other vascular pathologies. The inventors developed the humanized monoclonal antibody or antigen-binding fragment for detecting...
Published: 8/12/2021   |   Inventor(s): Stephen Black
Keywords(s):  
Category(s): Diagnostics, Therapeutics, Antibody
Effect of GHRH Antagonists in Type 2 Diabetes and Obesity
The current state of the art Triglyceride-rich-lipoproteins (TRL), that are generated in the small intestine as chylomicrons and the liver as very-low-density lipoprotein (VLDL), and their remnants represent an important risk factor for cardiovascular disease (DVD) in people with diabetes, obesities, or metabolic syndrome. The problems with the current...
Published: 6/3/2021   |   Inventor(s): Maritza Romero Lucas, Rudolf Lucas, Neal Weintraub, Andrew Schally, Renzhi Cai
Keywords(s):  
Category(s): Therapeutics
Use of arginase 1 as a treatment for retinopathy
The current state of the art Ischemia retinopathies cause retinal neurovascular injury and are a primary contributor to blinding disease that affects neonates (retinopathy of prematurity), working-age adults (diabetic retinopathy), and the elderly (branch vein occlusion and age-related macular degeneration). The problems with the current art Despite...
Published: 6/1/2021   |   Inventor(s): Ruth Caldwell, William Caldwell, Abdelrahman Fouda
Keywords(s):  
Category(s): Therapeutics
Title: Engineered Exosome Delivery System to detect and deplete pro-tumorigenic macrophages
The current state of the art: Despite the advancement in immunotherapy and other targeted therapy for the treatment of cancer, the success rate remains low in solid tumors. Targeting the tumor microenvironment (TME) is a new promising treatment strategy. Infiltrated in TME, tumor-associated macrophages, especially CD206 positive M2 macrophages, play...
Published: 5/28/2021   |   Inventor(s): Ali Arbab, Mohammad Rashid, Thaiz Borin, Roxan Ara
Keywords(s):  
Category(s): Diagnostics, Therapeutics
Novel TREM1 inhibitor for pathological inflammatory response
The current state of the art Trigging receptor expressed on myeloid cell 1 (TREM-1) plays a critical role in the pathogenesis of acute and chronic cardiovascular conditions, and is a crucial mediator of septic shock, especially, in cytokine release syndrome. Inhibiting TREM-1 is a promising therapeutic candidate for TREM-related diseases such as inflammatory...
Published: 5/26/2021   |   Inventor(s): Anatolij Horuzsko, Iryna Lebedyeva, Thomas Albers, Ashwin Ajith
Keywords(s):  
Category(s): Therapeutics
Adenovirus Survivin for Detection or Treatment of Uterine Leiomyosarcoma
The Current State of Art Uterine sarcoma, though with very low incidence (4% of uterine cancer), has a high malignant degree and poor prognosis. Leiomyosarcoma is the most common type of uterine sarcoma and usually occurs in women over 40 years. Proper differentiation between benign leiomyoma and malignant uterine leiomyosarcoma can dramatically improve...
Published: 5/25/2021   |   Inventor(s): Ayman Al-Hendy, Mostafa Khater
Keywords(s):  
Category(s): Diagnostics, Methods, Therapeutics
Deep Brain Stimulation for the Treatment of Non-Alzheimer's Dementia
The current state of the art The current treatment option for Alzheimer’s disease and aging related dementia are focused on the alleviation of symptoms and managing cognition. Degeneration of cholinergic neurons is one of the mechanisms leading to cognition declination. Therefore, aging and Alzheimer’s dementia is commonly treated with...
Published: 5/25/2021   |   Inventor(s): Cole Giller, David Blake, David Hess, Alvin Terry, Jr., John Morgan, Gregory Lee, Jonathan Crawford, Ruifeng Liu, Christos Constantinidis
Keywords(s):  
Category(s): Therapeutics
Methods and Compositions for Treating Neurodegenarative Diseases
The current state of the art: Neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and multiple sclerosis pose devastating threats to both patients and their caregivers. Although palliative measurements are available to manage the disease symptoms, effective...
Published: 3/25/2021   |   Inventor(s): Robert Yu, Yutaka Itokazu
Keywords(s):  
Category(s): Therapeutics
Compositions and methods to increase the resistance of adoptive transfer of T cells to immunosuppression
The current state of the art: Cancer immunotherapy resurrects the patients’ suppressed immune system by increasing the immunogenicity of T cells such as the adoptive transfer of T cells (TCR and CAR T cells) and removing suppression of immune checkpoints such as PD-1/L1. Many cancer immunotherapies have been approved by the FDA. For example,...
Published: 3/16/2021   |   Inventor(s): Pandelakis Koni, Esteban Celis
Keywords(s):  
Category(s): Therapeutics
Compositions and Methods for treating diabetes
The current state of the art About 10% of the US population, 34.2 million people, have diabetes and about 34.5% of the US adults, 88 million people, have prediabetes (higher than normal blood sugar). Exercise has been shown to improve glycemic control in patients with type 2 diabetes through increasing energy expenditure and insulin-induced membrane...
Published: 3/11/2021   |   Inventor(s): Babak Baban, Jack Yu, Vanessa Hale
Keywords(s):  
Category(s): Therapeutics
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