Premature ovarian failure (POP) is defined as hypergonadotropic ovarian failure occurring prior to age 40. AU researchers used human bone marrow mesenchymal stem cells to reverse infertility in a chemotherapy induced ovarian failure mouse model. The cells were delivered by direct intra-ovarian injection. The treatment were successful with all treated mice achieving viable pregnancy and producing pups, overall the number of pups were about 30% compared to that achieved by healthy controls. All delivered pups appeared with normal morphology with no apparent anomalies or abnormalities. They were not significantly different in weight compared to healthy controls.