Use of GILZ for Hair Growth


The current state of art:

Hair loss, also known as androgenetic alopecia affects roughly 50% of men and 75% of women older than 65 years. In the US, it affects an estimated 50 million men and 30 million women. Current FDA-approved drugs for hair loss include Finasteride and Minoxidil.


Problems with current state of art:

However, Finasteride, a 5α-reductase inhibitor, has caused undesirable adverse effects such as impotence and reduced libido. Although Minoxidil has not shown any safety concern, the efficacy of Minoxidil is low: less than 40% of the patients responded to twice daily topical application of Minoxidil in a clinical study. A safer and more effective medication is needed to treat hair loss. 


Advantages of our invention:

Scientists at AU have identified the novel effect of glucocorticoid-induced leucine zipper (GILZ) fusion protein in promoting hair growth. In a mouse study, the GILZ, fused with a cell-penetrating-protein induced proliferation and maturation of hair follicles at the site of injection when administered to the skin at a 3-day interval. GILZ is ubiquitously expressed in the body and has an anti-inflammation effect. Therefore, GILZ is a promising treatment for hair loss. 


AURI # 2019-014

IP status: US non-provisional 16/599,397 filed in 11/12/2019


Patent Information:
For Information, Contact:
Lei Wan
Technology Transfer Associate
Augusta University
Mahmood Mozaffari
Babak Baban
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