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A Mouse Model for Mental Disorders and Epilepsy
Current State of the Art The Neuregulin/ErbB4 signaling pathway is involved in GABAergic neurotransmission, an important inhibitory neurotransmission that regulates several processes in the central nervous system including muscle tone. Aberrant GABAergic function has been implicated in Schizophrenia, Schizo-affective disorder and in Epilepsy...
Published: 1/9/2013   |   Inventor(s): Lin Mei, Wen-cheng Xiong
Keywords(s): Drug Discovery, Drug Testing, Epilepsy, Mouse, Schizophrenia
Category(s): Research Tools
Hsp110 Plays a Critical Role in Tau Hyperphosphorylation and Tauopathies (e.g., Alzheimer’s Disease, ALS, Parkinson’s, and Others)
State of the Art:Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), are considered to be protein misfolding disorders. Heat shock proteins provide a line of defense against protein misfolding disorders and are among the most potent suppressors of neurodegeneration in animal models. Several different heat shock protei...
Published: 11/13/2012   |   Inventor(s): Nahid Mivechi, Binnur Eroglu, Dimitrios Moskophidis
Keywords(s): ALS, Alzheimer's Disease, Mouse, Parkinson's Disease
Category(s): Research Tools
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