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Erbin as a Target to Regulate ErbB2 and Neuregulin Signaling
AU researchers found that erbin is a protein that interacts with ErbB2 and is critical for its expression on the surface membrane. ErbB2 becomes unstable when erbin expression is inhibited by a small interference RNA. ErbB2 is one of the most potent oncogenes in tumor genesis and metastasis. This therapeutic agent competes favorably with other drug...
Published: 5/1/2018   |   Inventor(s): Lin Mei, Wen-cheng Xiong, Yanmei Tao
Keywords(s):  
Category(s): Therapeutics
Novel Target and New Breast Cancer Drugs for Chemo-Resistant Tumors
Researchers at AU discovered that Erbin, an ErbB2 interacting protein is necessary for the ErbB2-dependent growth of tumor cells. They prepared small peptides that disrupt the Erbin-ErbB2 interaction, increase ErbB2 degradation, and inhibit growth of tumor cells. Injection of the peptide into tumors in nude mice inhibit tumor growth.
Published: 5/11/2017   |   Inventor(s): Lin Mei, Wen-cheng Xiong, Cheng-yong Shen, Yanmei Tao, Shiwen Luo
Keywords(s):  
Category(s): Therapeutics
A Mouse Model for Mental Disorders and Epilepsy
Current State of the Art The Neuregulin/ErbB4 signaling pathway is involved in GABAergic neurotransmission, an important inhibitory neurotransmission that regulates several processes in the central nervous system including muscle tone. Aberrant GABAergic function has been implicated in Schizophrenia, Schizo-affective disorder and in Epilepsy...
Published: 1/9/2013   |   Inventor(s): Lin Mei, Wen-cheng Xiong
Keywords(s): Drug Discovery, Drug Testing, Epilepsy, Mouse, Schizophrenia
Category(s): Research Tools
Netrin-1 as a Potential Target for Diagnosis and Treatment of Male Fertility and Infertility Associated Disorders
Current State of the ArtMale infertility can range from low or no production of sperm to poor motility in mature sperm. Treatments for male infertility include surgery that can involve removing occlusions that block sperm motility or direct harvesting of the sperm. Medications are used that increase sperm production. These include gonadotropins, te...
Published: 9/6/2011   |   Inventor(s): Wen-cheng Xiong, Jae-ho Lee, Lin Mei
Keywords(s):  
Category(s): Therapeutics
A Mouse Model for Neurodegenerative Disorders
Model for Alzheimers Disease · Vps35 mutant · Increased amyloid and tau pathologies · Defects in: o Spatial learning and memory o Long term potentiation o Glutaminergic transmission · Inventor: Wen-Cheng Xiong, PhD; Lin Mei, PhD Case Number: GHSU 2012-008 Material Transfer Agreements for Pr...
Published: 9/6/2011   |   Inventor(s): Wen-cheng Xiong, Lin Mei
Keywords(s):  
Category(s): Research Tools
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