Search Results - wen-cheng+xiong

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A Mouse Model for Mental Disorders and Epilepsy

Current State of the Art The Neuregulin/ErbB4 signaling pathway is involved in GABAergic neurotransmission, an important inhibitory neurotransmission that regulates several processes in the central nervous system including muscle tone. Aberrant GABAergic function has been implicated in Schizophrenia, Schizo-affective disorder and in Epilepsy....

Published: 4/29/2020 | Inventor(s): Lin Mei, Wen-Cheng Xiong

Keywords(s): Drug Discovery, Drug Testing, Epilepsy, Mouse, Schizophrenia

Category(s): Research Tools

Erbin as a Target to Regulate ErbB2 and Neuregulin Signaling

AU researchers found that erbin is a protein that interacts with ErbB2 and is critical for its expression on the surface membrane. ErbB2 becomes unstable when erbin expression is inhibited by a small interference RNA. ErbB2 is one of the most potent oncogenes in tumor genesis and metastasis. This therapeutic agent competes favorably with other drugs...

Published: 10/19/2020 | Inventor(s): Lin Mei, Wen-Cheng Xiong, Yanmei Tao

Keywords(s):

Category(s): Therapeutics

Novel Composition for HER2+ Cancer

The Current State of the Art: HER2 (also known as ErbB2), a receptor tyrosine kinase is overexpressed in around 25% of breast cancer cells. It is a known anti-cancer target to the monoclonal antibody, Trastuzumab. Limitation of the Current Art: However, about 20% patients develop resistance to Trastuzumab. Pertuzumab, Lapatinib, and other trastuzumab...

Published: 3/31/2022 | Inventor(s): Lin Mei, Wen-Cheng Xiong, Cheng-Yong Shen, Yanmei Tao, Shiwen Luo

Keywords(s):

Category(s): Therapeutics

Netrin-1 as a Potential Target for Diagnosis and Treatment of Male Fertility and Infertility Associated Disorders

Current State of the Art Male infertility can range from low or no production of sperm to poor motility in mature sperm. Treatments for male infertility include surgery that can involve removing occlusions that block sperm motility or direct harvesting of the sperm. Medications are used that increase sperm production. These include gonadotropins, testosterone...

Published: 8/18/2021 | Inventor(s): Wen-Cheng Xiong, Jae-Ho Lee, Lin Mei

Keywords(s):

Category(s): Therapeutics

A Mouse Model for Neurodegenerative Disorders

Model for Alzheimers Disease · Vps35 mutant · Increased amyloid and tau pathologies · Defects in: o Spatial learning and memory o Long term potentiation o Glutaminergic transmission · Inventor: Wen-Cheng Xiong, PhD; Lin Mei, PhD Case Number: GHSU 2012-008 Material Transfer Agreements for Profit...

Published: 7/29/2016 | Inventor(s): Wen-Cheng Xiong, Lin Mei

Keywords(s):

Category(s): Research Tools