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Curcumin Conjugates and Methods of Use Thereof

The current state of the art Breast cancer is the second most common cancer in women with an estimated 268,600 cases in 2019 and 41,760 deaths in the US. Curcumin, a phenolic compound and the major ingredient in the spice, turmeric, has anti-inflammatory and pro-apoptotic activities against many solid tumors. The problems with the current art Curcumin...

Published: 8/31/2022 | Inventor(s): Siva Panda, Muthusamy Thangaraju, Balakrishna Lokeshwar

Keywords(s):

Category(s): Therapeutics

Ibuprofen hybrid conjugates as potential anti-inflammatory and analgesic agents

The current state of the art: Nonsteroidal anti-inflammatory drugs (NSAIDs) have broad therapeutic use that ranges from the treatment for fever, inflammation, and mild pain to severe chronic inflammatory disorders. NSAIDs mainly act by COX 1 inhibition, the key enzymes capable of the conversion of arachidonic acid to prostaglandins. Therefore, the...

Published: 8/31/2022 | Inventor(s): Siva Panda

Keywords(s):

Category(s): Therapeutics

Pyrazinoic acid-isoniazid hybrid conjugates’ antimycobacterial and antibacterial properties

The current state of the art: Tuberculosis is one of the top 10 causes of death worldwide. Patients are treated for two months with first-line drugs including isoniazid, rifampin, pyrazinamide, and ethambutol, followed by another four months of isoniazid and rifampin alone. The problems of the current art: However, the multidrug-resistant disease...

Published: 8/31/2022 | Inventor(s): Siva Panda

Keywords(s):

Category(s): Therapeutics

Curcumin conjugates for the treatment of inflammation-associated disease

The current state of the art: Inflammation is associated with many serious diseases, for example, rheumatoid arthritis, chronic hepatitis, myocardial infarction, brain ischemic injury, cancer, and pulmonary diseases. Anti-inflammatory drugs such as non-steroidal (including ibuprofen, naproxen, indomethacin, etc) and COX2 inhibitors have been in the...

Published: 8/31/2022 | Inventor(s): Siva Panda

Keywords(s):

Category(s): Therapeutics