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Development of an Endothelial Nitric Oxide Synthase Mutant Resistant to Inhibition by Oxidative Stress for the Treatment of Endothelial Dysfunction
Current State of the Art:A major complication of vascular disease is endothelial dysfunction caused by oxidative stress to the vasculature.  Treatment options include surgery, implantation of stints, medications and lifestyle changes.  Currently there are no gene therapy treatments available for endothelial dysfunction.  Available chemical and phar...
Published: 8/14/2019   |   Inventor(s): Stephen Black, Ruslan Rafikov
Keywords(s):  
Category(s): Therapeutics
Nitration Shielding Peptides and Methods for Inhibiting Nitration of Proteins
TitleNitration Shielding Peptides and Methods for Inhibiting Nitration of ProteinsCurrent State of the ArtElevated nitration of proteins is associated with different diseases and disorders. Effective inhibition of nitration of proteins is an active area of research for drug discoverers.Problems with the Current ArtCurrent methods of treating protei...
Published: 8/20/2015   |   Inventor(s): Stephen Black, Ruslan Rafikov
Keywords(s):  
Category(s): Therapeutics
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