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Antibody specific for PKG-1alpha nitration

Scientists at AU identified that nitration of PKG-1α in tyrosine 247 attenuates the catalytic activity of PKG-1 α, which plays a critical role in the development of vascular dysfunction in pulmonary hypertension and other vascular pathologies. The inventors developed the humanized monoclonal antibody or antigen-binding fragment for detecting...

Published: 3/31/2022 | Inventor(s): Stephen Black

Keywords(s):

Category(s): Diagnostics, Therapeutics, Antibody

Composition and Use of Nitration Shielding Peptides in Diseases with Elevated Protein Nitration

Title Composition and Use of Nitration Shielding Peptides in Diseases with Elevated Protein Nitration Current State of the Art Elevated nitration of proteins is associated with different diseases and disorders such as acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Effective inhibition of nitration of proteins is an active...

Published: 5/7/2020 | Inventor(s): Stephen Black, Ruslan Rafikov

Keywords(s):

Category(s): Therapeutics