Search Results - diagnostics

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The current state of the art:Gliomas account for about 27% of all brain tumors and about 80% of the malignant tumors. Currently, Glioma is classified by histology and the gene mutation test (isocitrate dehydrogenase, IDH) defined by the world health organization (WHO).The problems with the current art:However, there is a big discrepancy between histology...

Published: 4/7/2023 | Inventor(s): Jin-Xiong She, Paul Tran

Keywords(s):

Category(s): Diagnostics

Antibody specific for PKG-1alpha nitration

Scientists at AU identified that nitration of PKG-1α in tyrosine 247 attenuates the catalytic activity of PKG-1 α, which plays a critical role in the development of vascular dysfunction in pulmonary hypertension and other vascular pathologies. The inventors developed the humanized monoclonal antibody or antigen-binding fragment for detecting...

Published: 3/31/2022 | Inventor(s): Stephen Black

Keywords(s):

Category(s): Diagnostics, Therapeutics, Antibody

Title: Engineered Exosome Delivery System to detect and deplete pro-tumorigenic macrophages

The current state of the art: Despite the advancement in immunotherapy and other targeted therapy for the treatment of cancer, the success rate remains low in solid tumors. Targeting the tumor microenvironment (TME) is a new promising treatment strategy. Infiltrated in TME, tumor-associated macrophages, especially CD206 positive M2 macrophages, play...

Published: 7/12/2022 | Inventor(s): Ali Arbab, Mohammad Rashid, Thaiz Borin, Roxan Ara

Keywords(s):

Category(s): Diagnostics, Therapeutics

Adenovirus Survivin for Detection or Treatment of Uterine Leiomyosarcoma

The Current State of Art Uterine sarcoma, though with very low incidence (4% of uterine cancer), has a high malignant degree and poor prognosis. Leiomyosarcoma is the most common type of uterine sarcoma and usually occurs in women over 40 years. Proper differentiation between benign leiomyoma and malignant uterine leiomyosarcoma can dramatically improve...

Published: 5/25/2021 | Inventor(s): Ayman Al-Hendy, Mostafa Khater

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Category(s): Diagnostics, Methods, Therapeutics

Quantification by Ultrafiltration and Immunofixation Electrophoresis Testing (QUIET) for monoclonal serum free light chains

The current state of the art: Plasma cell myelomas is a plasma cell disorder that is associated with the presence of monoclonal immunoglobulin or fragments secreted by a B-cell clone. It can be detected and monitored by the presence of free monoclonal light chains. Currently, the serum free-light-chain (sFLC) assay is the most analytically sensitive...

Published: 4/7/2023 | Inventor(s): Gurmukh Singh, Roni Bollag

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Category(s): Diagnostics, Methods, Research Tools

Blockchain Technology with Hybrid Models: Health Analytics and Pre-emptive Therapy options to save patients

The current state of the art:Healthcare-associated infection (HAI) places a significant burden on the patients and the health care system. It is estimated that 3% of hospitalized patients had one or more HAI in 2015. It accounts for about 1.7 million infections and 99,000 death per year. On the other hand, the Centers for Medicare and Medicaid Services...

Published: 3/6/2020 | Inventor(s): Arni Rao, Jose Vazquez, Luis Ostrosky

Keywords(s):

Category(s): Diagnostics

A Novel SUMO-like Gene for Type 1 Diabetes Susceptibility

Current State of the Art: Type 1 diabetes is an organ-specific autoimmune disease with aberrant immune responses to specific β-cell autoantigens. Prevention is important because diabetes interrupts normal development in children and carries the threat of severe complications in the most active period of life. Both environmental and genetic...

Published: 4/28/2020 | Inventor(s): Jin-Xiong She, Cong-Yi Wang

Keywords(s): Diabetes II, Genomics

Category(s): Diagnostics

Sensitive Detection of Peptide Fragments Specific to Galectin-3 for the Detection and Monitoring of Well-differentiated Thyroid Cancer, Head and Neck Cancer, Lung Cancer, Colorectal Cancer and Other Cancers and Disease States

Current State of the Art:The detection of head and neck cancers, i.e. thyroid cancers, colorectal and other types of cancers are normally done via MRI or other non-specific tests. Problems with the Current Art:Such tests are not as accurate or time sensitive to identify the progression of the tumor in its early stage.Advantages of the Novel Invention:...

Published: 4/28/2020 | Inventor(s): Paul Weinberger, John Koomen, William Dynan, David Terris, Sunny Khichi, Mark Merkley

Keywords(s): Cancer, Diagnostics, Peptides

Category(s): Diagnostics

Development of an Orthodontic Bracket Placement Device and Coordinated Bracket Placement System

Title: Orthodontic Bracket Placement Device and Coordinated Bracket Placement System Current State of the Art: Orthodontic brackets are used by general dentists and orthodontists throughout the world. The proper placement of these brackets is essential for eventual correction of poorly aligned teeth in both children and adults. In order to guide...

Published: 4/28/2020 | Inventor(s): John Stockstill

Keywords(s): Dental, Orthodontics

Category(s): Diagnostics

Gene for Successful Aging Without Cognitive Decline

Title: Biomarker for Successful Aging without Cognitive Decline Current State of the Art: It is estimated that up to one third of adults will experience a gradual decline in cognitive function known as mild cognitive impairment as they age. Individuals with cognitive decline are able to function reasonably well in everyday activities, such as managing...

Published: 6/21/2021 | Inventor(s): Shirley Poduslo

Keywords(s): Aging, Alzheimer's Disease, Therapeutics

Category(s): Diagnostics

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