Description:
Scientists at AU identified that nitration of PKG-1α in tyrosine 247 attenuates the catalytic activity of PKG-1 α, which plays a critical role in the development of vascular dysfunction in pulmonary hypertension and other vascular pathologies.
The inventors developed the humanized monoclonal antibody or antigen-binding fragment for detecting nitrated tyrosine 247 of PKG-1 α. Further, the antibody or antigen-binding fragment can be labeled with a detectable marker or conjugated to a second molecule, such as a radioisotope, a fluorescent compound, a bioluminescent compound, biotin, chemiluminescent compound, a metal chelator, or an enzyme. The labeled or conjugated antibody or antigen-binding fragment can be used to detect or treat diseases or disorders associated with nitrated tyrosine 247 of PKG-1 α.
AURI-2013-004*
Lead Inventor: Stephen Black
Patent Status: US 9551711
Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953305/