Prodrugs of Short-Chain Fatty Acids for Treatment of Intestinal Disorders and Colon Cancer



Current State of the Art:

Colon cancer, IBS, Crohn’s disease and colitis present as some of the most difficult diseases to treat with the medications available currently. Treatment can be as drastic as surgery, chemotherapy, medications, such as cortisone, which can have sometimes serious and debilitating side effects. Colon cancer is treated with radiation and chemotherapy. Crohn’s disease and ulcerative colitis are thought to be related to the autoimmune response and present many complications for which no single effective therapy exists.

Problems with the Current Art:

Use of chemotherapy and radiation to treat cancer patients leads to devastating side effects including weight loss, loss of energy (fatigue), hair loss, susceptibilty to infections, negative effects on healthy organ systems, among others.

Frequently, use of the cortisone family of drugs to treat Crohn’s disease and ulcerative colitis leads to systemic issues affecting healthy organs and significantly limits the quality of life for such patients.

IBS is currently treated with drugs that control neurotransmitter re-uptake and present with limited success rates that affect other organ systems as well.

Advantages of the Novel Invention:

The short chain fatty acids that are part of the normal biochemical pathway serve as a natural breakthrough method to administer pro-drugs that directly treat the source of the disease. The inventors have discovered the use of fatty acid esters attached to amino acids which will serve as substrates for the transport system. Use of a well-characterized amino acid transport system, which is highly up-regulated in diseases such as colon cancer cells, serves to better assist in the transport of pro-drug compounds with fewer side effects in the gastrointestinal system.

Case Number: GHSU 2004-024

Patent Information:
For Information, Contact:
Augusta University
Vadivel Ganapathy
Puttur Prasad
Robert Martindale
Colon Cancer
Inflammatory Bowel Disease
Ulcerative Colitis
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