Description:
Use of Sphingolipids in cell culture to inhibit pluripotent stem cell-derived teratoma formation
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)
The current state of the art:
Stem cells are capable of self-renewal into more and differentiation specialized cells, making them one of the most promising restorative medicine. However, the pluripotent stem cells can form fast-growing, noncancerous tumors called teratomas, which has impeded the development of stem cells into regenerative medicines.
The problems of the current art:
There are some experimental methods to inhibit teratoma formation. For example, beam radiation, transgene expression, and small molecules have been explored in preclinical models. However, strategies in human stem cell therapies are not available yet.
The advantage of our invention:
The scientists at AU developed a cell culture method with human sphingolipids, ceramide and sphingosine-1-phosphate (S1P), to inhibit pluripotent stem cells-derived-teratoma formation. Ceramide and its analogs such as S18 induced cell death of the pluripotent stem cells that are capable to form teratomas; S1P1 and its analogs such as FTY720 rescued the neural stem cells that react with S18 but do not form teratomas from apoptosis. As a result, neural stem cells can differentiate into oligodendrocytes precursors or oligodendrocytes without forming teratomas after transplantation in vivo.
The current invention can be used in human cell therapy or gene therapy to treat neural disease or disorders such as Alzheimer’s disease, nervous system injuries that arise from spinal cord injuries, stroke, or other neural trauma, and neural disease and damage
AURI # 2007-014
IP status: US7985586B2
Inventor: Erhard Bieberich, PhD https://www.augusta.edu/mcg/dnrm/faculty/bieberich.php
Figure Three subpopulations of EB-derived cells.