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Quantification by Ultrafiltration and Immunofixation Electrophoresis Testing (QUIET) for monoclonal serum free light chains

The current state of the art: Plasma cell myelomas is a plasma cell disorder that is associated with the presence of monoclonal immunoglobulin or fragments secreted by a B-cell clone. It can be detected and monitored by the presence of free monoclonal light chains. Currently, the serum free-light-chain (sFLC) assay is the most analytically sensitive...

Published: 4/7/2023 | Inventor(s): Gurmukh Singh, Roni Bollag

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Category(s): Diagnostics, Methods, Research Tools

A Mouse Model for Mental Disorders and Epilepsy

Current State of the Art The Neuregulin/ErbB4 signaling pathway is involved in GABAergic neurotransmission, an important inhibitory neurotransmission that regulates several processes in the central nervous system including muscle tone. Aberrant GABAergic function has been implicated in Schizophrenia, Schizo-affective disorder and in Epilepsy....

Published: 4/29/2020 | Inventor(s): Lin Mei, Wen-Cheng Xiong

Keywords(s): Drug Discovery, Drug Testing, Epilepsy, Mouse, Schizophrenia

Category(s): Research Tools

Protocol To Differentiate Adult-Type Neural Stem Cells Using Novel Ceramide Analogs (NCAs) and Sphingosine-1-Phosphate Receptor Agonists (SRAs)

Use of Sphingolipids in cell culture to inhibit pluripotent stem cell-derived teratoma formation The current state of the art: Stem cells are capable of self-renewal into more and differentiation specialized cells, making them one of the most promising restorative medicine. However, the pluripotent stem cells can form fast-growing, noncancerous...

Published: 6/19/2020 | Inventor(s): Erhard Bieberich

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Category(s): Therapeutics, Research Tools

Three-Dimensional Tumor Holder and Ruler in Live Mouse

Current State of the Art: In preclinical studies, subcutaneous tumor volume is measured by calibers and other imaging systems such as CT, MRI, and ultrasonography to monitor tumor growth, disease progression, and response to treatments. The imaging system measure tumors in sedative animals in three dimensions. On the other hand, calibers measure two...

Published: 11/22/2019 | Inventor(s): Fengchong Kong, Jian-Yue Jin, Christopher Middleton

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Category(s): Research Tools, Medical Devices

Tissue Chip Bioreactor for Tissue Engineering

Researchers at AU developed a full-scale prototype of a bioreactor for growing complex tissues in a scalable manner. This bioreactor chip can yield several mm tissues consisting of different cell types. Apart from tissue transplants it can also be used for high-throughput tissue engineering and pre-clinical replacement for animal models.

Published: 5/6/2020 | Inventor(s): Paul Weinberger, Donald Mettenburg, Frederick Rueggeberg

Keywords(s):

Category(s): Research Tools, Therapeutics

A Mouse Model for Neurodegenerative Disorders

Model for Alzheimers Disease · Vps35 mutant · Increased amyloid and tau pathologies · Defects in: o Spatial learning and memory o Long term potentiation o Glutaminergic transmission · Inventor: Wen-Cheng Xiong, PhD; Lin Mei, PhD Case Number: GHSU 2012-008 Material Transfer Agreements for Profit...

Published: 7/29/2016 | Inventor(s): Wen-Cheng Xiong, Lin Mei

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Category(s): Research Tools