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A Method for Multiple Site-Directed Mutagenesis of More than 10 Sites
Current State of the Art: Being able to genetically manipulate a living system is an essential tool in understanding how living systems work. Site directed mutagenesis strategies allow researchers to change DNA sequences to determine how this will influence the function of a protein or important DNA regulatory element. Site-Directed mutagenes...
Published: 8/13/2019   |   Inventor(s): Andreas Seyfang
Keywords(s): Genetic Engineering, Mutagenesis, Proteomics
Category(s): Research Tools
Cell-lineage Specific Expression in Transgenic Zebrafish
Transgenic Zebrafish technologies are incredibly valuable tools for internal and collaborative research. GHSU holds patent (6,380,458) and licensing rights for “Cell lineage specific expression in transgenic zebrafish”. The zebrafish research community is very large and highly collaborative. At GHSU we have several faculty of our own th...
Published: 8/13/2019   |   Inventor(s): Shuo Lin
Keywords(s): Development, Differentiation, Research Tool
Category(s): Research Tools
Hsp110 Plays a Critical Role in Tau Hyperphosphorylation and Tauopathies (e.g., Alzheimer’s Disease, ALS, Parkinson’s, and Others)
State of the Art:Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), are considered to be protein misfolding disorders. Heat shock proteins provide a line of defense against protein misfolding disorders and are among the most potent suppressors of neurodegeneration in animal models. Several different heat shock protei...
Published: 8/13/2019   |   Inventor(s): Nahid Mivechi, Binnur Eroglu, Dimitrios Moskofidis
Keywords(s): ALS, Alzheimer's Disease, Mouse, Parkinson's Disease
Category(s): Research Tools
A Mouse Model for Mental Disorders and Epilepsy
Current State of the Art The Neuregulin/ErbB4 signaling pathway is involved in GABAergic neurotransmission, an important inhibitory neurotransmission that regulates several processes in the central nervous system including muscle tone. Aberrant GABAergic function has been implicated in Schizophrenia, Schizo-affective disorder and in Epilepsy...
Published: 8/13/2019   |   Inventor(s): Lin Mei, Wen-Cheng Xiong
Keywords(s): Drug Discovery, Drug Testing, Epilepsy, Mouse, Schizophrenia
Category(s): Research Tools
Three-Dimensional Tumor Holder and Ruler in Live Mouse
Current State of the Art: In preclinical studies, subcutaneous tumor volume is measured by calibers and other imaging systems such as CT, MRI, and ultrasonography to monitor tumor growth, disease progression, and response to treatments. The imaging system measure tumors in sedative animals in three dimensions. On the other hand, calibers measure ...
Published: 8/8/2018   |   Inventor(s): Fengchong Kong, Jian-Yue Jin, Christopher Middleton
Keywords(s):  
Category(s): Research Tools, Medical Devices
Tissue Chip Bioreactor for Tissue Engineering
Researchers at AU developed a full-scale prototype of a bioreactor for growing complex tissues in a scalable manner. This bioreactor chip can yield several mm tissues consisting of different cell types. Apart from tissue transplants it can also be used for high-throughput tissue engineering and pre-clinical replacement for animal models.
Published: 7/20/2015   |   Inventor(s): Paul Weinberger, Donald Mettenburg, Frederick Rueggeberg
Keywords(s):  
Category(s): Research Tools, Therapeutics
A Mouse Model for Neurodegenerative Disorders
Model for Alzheimers Disease · Vps35 mutant · Increased amyloid and tau pathologies · Defects in: o Spatial learning and memory o Long term potentiation o Glutaminergic transmission · Inventor: Wen-Cheng Xiong, PhD; Lin Mei, PhD Case Number: GHSU 2012-008 Material Transfer Agreements for Pr...
Published: 9/6/2011   |   Inventor(s): Wen-Cheng Xiong, Lin Mei
Keywords(s):  
Category(s): Research Tools
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