Search Results - yanmei tao

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Erbin as a Target to Regulate ErbB2 and Neuregulin Signaling
AU researchers found that erbin is a protein that interacts with ErbB2 and is critical for its expression on the surface membrane. ErbB2 becomes unstable when erbin expression is inhibited by a small interference RNA. ErbB2 is one of the most potent oncogenes in tumor genesis and metastasis. This therapeutic agent competes favorably with other drug...
Published: 5/1/2018   |   Inventor(s): Lin Mei, Wen-Cheng Xiong, Yanmei Tao
Category(s): Therapeutics
Novel Target and New Breast Cancer Drugs for Chemo-Resistant Tumors
Researchers at AU discovered that Erbin, an ErbB2 interacting protein is necessary for the ErbB2-dependent growth of tumor cells. They prepared small peptides that disrupt the Erbin-ErbB2 interaction, increase ErbB2 degradation, and inhibit growth of tumor cells. Injection of the peptide into tumors in nude mice inhibit tumor growth.
Published: 5/11/2017   |   Inventor(s): Lin Mei, Wen-Cheng Xiong, Cheng-Yong Shen, Yanmei Tao, Shiwen Luo
Category(s): Therapeutics
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