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Erbin as a Target to Regulate ErbB2 and Neuregulin Signaling

AU researchers found that erbin is a protein that interacts with ErbB2 and is critical for its expression on the surface membrane. ErbB2 becomes unstable when erbin expression is inhibited by a small interference RNA. ErbB2 is one of the most potent oncogenes in tumor genesis and metastasis. This therapeutic agent competes favorably with other drugs...

Published: 10/19/2020 | Inventor(s): Lin Mei, Wen-Cheng Xiong, Yanmei Tao

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Category(s): Therapeutics

Novel Composition for HER2+ Cancer

The Current State of the Art: HER2 (also known as ErbB2), a receptor tyrosine kinase is overexpressed in around 25% of breast cancer cells. It is a known anti-cancer target to the monoclonal antibody, Trastuzumab. Limitation of the Current Art: However, about 20% patients develop resistance to Trastuzumab. Pertuzumab, Lapatinib, and other trastuzumab...

Published: 3/31/2022 | Inventor(s): Lin Mei, Wen-Cheng Xiong, Cheng-Yong Shen, Yanmei Tao, Shiwen Luo

Keywords(s):

Category(s): Therapeutics