Erbin as a Target to Regulate ErbB2 and Neuregulin Signaling


AU researchers found that erbin is a protein that interacts with ErbB2 and is critical for its expression on the surface membrane. ErbB2 becomes unstable when erbin expression is inhibited by a small interference RNA. ErbB2 is one of the most potent oncogenes in tumor genesis and metastasis. This therapeutic agent competes favorably with other drugs used to disrupt ErbB2's function.

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For Information, Contact:
Carl Clark
Director Technology Transfer
Augusta University
Lin Mei
Wen-Cheng Xiong
Yanmei Tao
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